青春期的慢性不可预测压力会导致长期焦虑。
Chronic unpredictable stress during adolescence causes long-term anxiety.
作者信息
Chaby L E, Cavigelli S A, Hirrlinger A M, Caruso M J, Braithwaite V A
机构信息
Center for Brain, Behavior, and Cognition, Pennsylvania State University, University Park, PA 16802, United States; Department of Ecosystem Science & Management, Pennsylvania State University, University Park, PA 16802, United States; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, United States.
Center for Brain, Behavior, and Cognition, Pennsylvania State University, University Park, PA 16802, United States; Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802, United States; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, United States.
出版信息
Behav Brain Res. 2015 Feb 1;278:492-5. doi: 10.1016/j.bbr.2014.09.003. Epub 2014 Oct 22.
Exposure to stress during adolescence can cause long-term changes in behavior and cognition. Anxiety diagnoses rise during adolescence and are increased by adverse experiences. Currently, it is unknown how long stress during adolescence alters anxiety in adulthood. We found that rats exposed to chronic unpredictable stress during adolescence expressed altered behavior 6.5 months later; showing increased anxiety in a feeding test in a novel environment. Although behavioral changes indicative of anxiety were detected in late adulthood, the basal levels of fecal corticoid metabolites in prior-stressed rats did not differ from unstressed, control rats.
青春期暴露于应激状态会导致行为和认知的长期改变。焦虑症的诊断在青春期有所增加，且不良经历会使其进一步上升。目前，尚不清楚青春期的应激状态会在多长时间内改变成年期的焦虑状况。我们发现，青春期暴露于慢性不可预测应激的大鼠在6.5个月后出现了行为改变；在新环境中的进食测试中表现出焦虑增加。尽管在成年后期检测到了表明焦虑的行为变化，但先前受到应激的大鼠粪便皮质醇代谢物的基础水平与未受应激的对照大鼠并无差异。
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