ABC 转运蛋白 AbcB3 介导 D. discoideum 发育中的 cAMP 输出。
The ABC transporter, AbcB3, mediates cAMP export in D. discoideum development.
机构信息
Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Dev Biol. 2015 Jan 15;397(2):203-11. doi: 10.1016/j.ydbio.2014.11.006. Epub 2014 Nov 20.
Abstract
Extracellular cAMP functions as a primary ligand for cell surface cAMP receptors throughout Dictyostelium discoideum development, controlling chemotaxis and morphogenesis. The developmental consequences of cAMP signaling and the metabolism of cAMP have been studied in great detail, but it has been unclear how cells export cAMP across the plasma membrane. Here we show pharmacologically and genetically that ABC transporters mediate cAMP export. Using an evolutionary-developmental biology approach, we identified several candidate abc genes and characterized one of them, abcB3, in more detail. Genetic and biochemical evidence suggest that AbcB3 is a component of the cAMP export mechanism in D. discoideum development.
摘要
细胞外 cAMP 作为一种主要的配体，通过细胞表面的 cAMP 受体在整个盘基网柄菌发育过程中发挥作用，控制着趋化性和形态发生。cAMP 信号转导和 cAMP 的代谢的发育后果已经被深入研究，但细胞如何将 cAMP 穿过质膜输出仍不清楚。在这里，我们通过药理学和遗传学方法表明 ABC 转运蛋白介导 cAMP 输出。通过一种进化发育生物学的方法，我们鉴定了几个候选的 abc 基因，并进一步详细描述了其中一个基因，abcB3。遗传和生化证据表明，AbcB3 是 D. discoideum 发育中 cAMP 输出机制的一个组成部分。
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本文引用的文献
1
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PLoS One. 2013 Aug 14;8(8):e70040. doi: 10.1371/journal.pone.0070040. eCollection 2013.
2
Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.环核苷酸区室化：磷酸二酯酶和 ATP 结合盒转运蛋白的贡献。
Annu Rev Pharmacol Toxicol. 2013;53:231-53. doi: 10.1146/annurev-pharmtox-010611-134609. Epub 2012 Oct 16.
3
Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.分析与共济失调毛细血管扩张症突变基因相关 Rad3 相关蛋白激酶（ATR）的 G(2)期和必需 S 期功能分离的突变。
J Biol Chem. 2011 Oct 28;286(43):37320-7. doi: 10.1074/jbc.M111.276113. Epub 2011 Sep 9.
4
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.Thr-1989 磷酸化是活跃的共济失调毛细血管扩张突变相关基因和 Rad3 相关激酶（ATR）的标志物。
J Biol Chem. 2011 Aug 19;286(33):28707-28714. doi: 10.1074/jbc.M111.248914. Epub 2011 Jun 24.
5
Self-recognition in social amoebae is mediated by allelic pairs of tiger genes.在社会性粘菌中，自我识别是由老虎基因的等位基因对介导的。
Science. 2011 Jul 22;333(6041):467-70. doi: 10.1126/science.1203903. Epub 2011 Jun 23.
6
Developmental changes in transcriptional profiles.转录谱的发育变化。
Dev Growth Differ. 2011 May;53(4):567-75. doi: 10.1111/j.1440-169X.2010.01241.x. Epub 2011 Mar 30.
7
Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum.黏菌的社会阿米巴 Dictyostelium discoideum 和 Dictyostelium purpureum 的比较基因组学。
Genome Biol. 2011;12(2):R20. doi: 10.1186/gb-2011-12-2-r20. Epub 2011 Feb 28.
8
Evolutionary crossroads in developmental biology: Dictyostelium discoideum.发育生物学中的进化十字路口：盘基网柄菌。
Development. 2011 Feb;138(3):387-96. doi: 10.1242/dev.048934.
9
Conserved developmental transcriptomes in evolutionarily divergent species.进化上差异较大的物种中保守的发育转录组。
Genome Biol. 2010;11(3):R35. doi: 10.1186/gb-2010-11-3-r35. Epub 2010 Mar 17.
10
Polymorphic members of the lag gene family mediate kin discrimination in Dictyostelium.lag基因家族的多态性成员介导了盘基网柄菌中的亲缘识别。
Curr Biol. 2009 Apr 14;19(7):567-72. doi: 10.1016/j.cub.2009.02.037. Epub 2009 Mar 12.
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