Smith Nicola
Department of Paediatric Surgery, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.
Early Hum Dev. 2014 Dec;90(12):947-50. doi: 10.1016/j.earlhumdev.2014.09.012. Epub 2014 Nov 7.
Oesophageal atresia with tracheo-oesophageal fistula is a relatively common congenital anomaly occurring in around 1:2500 births. The aetiology and embryology of the condition remain unclear, whilst associations with other significant anomalies are common. Studies in rodent models are contributing to our understanding of the condition. Advances in surgical care and neonatal management have improved survival considerably to around 90%. Long-gap and isolated oesophageal atresia present significant management challenges. Post-operative and long-term complications including oesophageal stricture, gastro-oesophageal reflux and respiratory compromise however remain relatively common and continue to pose a challenge for the ongoing management of patients.
食管闭锁合并气管食管瘘是一种相对常见的先天性畸形，发生率约为1:2500活产儿。该病的病因和胚胎学尚不清楚，同时常伴有其他严重畸形。对啮齿动物模型的研究有助于我们了解这种疾病。外科治疗和新生儿管理的进展已使存活率大幅提高至约90%。长段型和孤立型食管闭锁带来了重大的管理挑战。然而，术后及长期并发症，包括食管狭窄、胃食管反流和呼吸功能不全仍然相对常见，继续对患者的持续管理构成挑战。
