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食管闭锁合并气管食管瘘术后早期并发症的管理:一项回顾性研究

Management of Early Post-Operative Complications of Esophageal Atresia With Tracheoesophageal Fistula: A Retrospective Study.

作者信息

Syed Muhammad Khalid, Al Faqeeh Ahmad A, Othman Alsayed, Almas Talal, Khedro Tarek, Alsufyani Reema, Almubarak Dana, Al Faqeh Rehab, Syed Saifullah, Syed Sabahat K

机构信息

Consultant Pediatric Surgery, King Fahad Hospital, Al Bahah, SAU.

Pediatric Surgery, King Fahad Hospital, Al Bahah, SAU.

出版信息

Cureus. 2020 Dec 4;12(12):e11904. doi: 10.7759/cureus.11904.

Abstract

Background Esophageal atresia (EA) with tracheoesophageal fistula (TEF) is a rare congenital malformation of the trachea and the esophagus. While the condition can result in a debilitating clinical picture, its outcomes have significantly ameliorated in recent times. The diminishing mortality associated with the disease can be attributed to a myriad of factors, including surgical advances, specialized anesthetic care, and categorical ventilator provision. These advances have resulted in increased survival rates even in premature infants who present with exceedingly low birth weights. Nevertheless, the mortality surrounding the condition still remains exceedingly high in some parts of the world, including the Middle East and Asia. The aim of the present study is to identify and outline the management of the postoperative complications that are intricately linked with soaring mortality rates. Methods We conducted a single-center retrospective study, three years in duration, of all the patients who were operated for esophageal atresia with tracheoesophageal fistula. The exclusion criteria included patients who died before the operation and those who were referred to other centers for management. The study evaluated several factors, including the various postoperative complications, their adept management, and the eventual outcomes. Data pertaining to the patient demographics, treatment, and radiological and laboratory findings was obtained and eventually analyzed using the Statistical Package for Social Sciences (SPSS) version 23.0 (IBM Corp., Armonk, NY, USA) software. Results The present study included a total of 12 cases diagnosed in our hospital during the aforementioned study period. Of these patients, two patients (16.7%) died before operation because of associated severe congenital anomalies such as cardiac pathologies. Three patients were referred to other centers for management. These patients were excluded from our analysis. The remaining seven patients were included in our analysis. In our study, gastroesophageal reflux was the most common postoperative complication and was noted in six patients. Leakage of anastomosis was noted in two patients. Lung collapse was noted in merely one patient and was thus the least common complication. The overall mortality rate hovered around 28.6%. Conclusions While most patients who are surgically managed for esophageal atresia with tracheoesophageal fistula develop postoperative complications, these complications are amenable to conservative management through the means of antibiotics, ventilator support, and total parenteral nutrition.

摘要

背景

食管闭锁(EA)合并气管食管瘘(TEF)是一种罕见的气管和食管先天性畸形。虽然这种疾病会导致令人衰弱的临床表现,但近年来其治疗结果有了显著改善。与该疾病相关的死亡率下降可归因于多种因素,包括手术进展、专业麻醉护理和分类通气设备的提供。这些进展使得即使是出生体重极低的早产儿存活率也有所提高。然而,在世界上一些地区,包括中东和亚洲,围绕该疾病的死亡率仍然极高。本研究的目的是识别并概述与飙升的死亡率密切相关的术后并发症的管理。方法:我们对所有因食管闭锁合并气管食管瘘而接受手术的患者进行了一项为期三年的单中心回顾性研究。排除标准包括术前死亡的患者以及被转诊至其他中心进行治疗的患者。该研究评估了几个因素,包括各种术后并发症、其适当的管理以及最终结果。获取了与患者人口统计学、治疗以及放射学和实验室检查结果相关的数据,并最终使用社会科学统计软件包(SPSS)23.0版(美国纽约州阿蒙克市IBM公司)软件进行分析。结果:在上述研究期间,本研究共纳入了我院诊断的12例患者。在这些患者中,有2例患者(16.7%)因伴有严重先天性畸形如心脏疾病而在术前死亡。3例患者被转诊至其他中心进行治疗。这些患者被排除在我们的分析之外。其余7例患者被纳入我们的分析。在我们的研究中,胃食管反流是最常见的术后并发症,6例患者出现该并发症。2例患者出现吻合口漏。仅1例患者出现肺不张,因此是最不常见的并发症。总体死亡率约为28.6%。结论:虽然大多数接受手术治疗的食管闭锁合并气管食管瘘患者会出现术后并发症,但这些并发症可通过抗生素、通气支持和全胃肠外营养等手段进行保守治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b76a/7781882/559d72788291/cureus-0012-00000011904-i01.jpg

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