食管闭锁及气管食管瘘
Oesophageal atresia and tracheo-oesophageal fistula.
作者信息
Goyal A, Jones M O, Couriel J M, Losty P D
机构信息
Royal Liverpool Children's Hospital (Alder Hey), Eaton Road, Liverpool L12 2AP, UK.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2006 Sep;91(5):F381-4. doi: 10.1136/adc.2005.086157.
Abstract
Oesophageal atresia-tracheo-oesophageal fistula has featured in paediatric surgery since its beginnings. The first successful primary repair was in 1941. With overall survival now exceeding 90% in dedicated centres, the emphasis has changed to reducing morbidity and achieving improvements in the quality of life. An overview of current and emerging strategies in managing patients with this condition is presented. Advances in developmental biology and molecular genetics reflecting improved understanding of the pathogenesis are highlighted.
摘要
自小儿外科诞生以来，食管闭锁-气管食管瘘一直是其关注的病症。1941年首次成功进行了一期修复手术。在专业中心，目前总体生存率已超过90%，重点已转向降低发病率并提高生活质量。本文概述了当前及新出现的针对该病症患者的治疗策略。文中强调了发育生物学和分子遗传学方面的进展，这些进展反映了对发病机制有了更好的理解。
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