Rizvi Irum, Choudhury Nirupam Roy, Tuteja Narendra
Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
Arch Virol. 2015 Feb;160(2):375-87. doi: 10.1007/s00705-014-2297-7. Epub 2014 Dec 2.
Geminiviruses are DNA viruses that infect several economically important crops, resulting in a reduction in their overall yield. These plant viruses have circular, single-stranded DNA genomes that replicate mainly by a rolling-circle mechanism. Geminivirus infection results in crosstalk between viral and cellular factors to complete the viral life cycle or counteract the infection as part of defense mechanisms of host plants. The geminiviral replication initiator protein Rep is the only essential viral factor required for replication. It is multifunctional and is known to interact with a number of host factors to modulate the cellular environment or to function as a part of the replication machinery. This review provides a holistic view of the research related to the viral Rep protein and various host factors involved in geminiviral DNA replication. Studies on the promiscuous nature of geminiviral satellite DNAs are also reviewed.
双生病毒是一类DNA病毒，可感染多种具有重要经济价值的作物，导致其总产量下降。这些植物病毒具有环状单链DNA基因组，主要通过滚环机制进行复制。双生病毒感染会导致病毒因子与细胞因子之间发生相互作用，以完成病毒生命周期或作为宿主植物防御机制的一部分来对抗感染。双生病毒复制起始蛋白Rep是复制所需的唯一必需病毒因子。它具有多种功能，已知可与多种宿主因子相互作用，以调节细胞环境或作为复制机制的一部分发挥作用。本综述全面介绍了与病毒Rep蛋白以及双生病毒DNA复制中涉及的各种宿主因子相关的研究。同时也对双生病毒卫星DNA的混杂性质研究进行了综述。
