Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia; Department of Neurology, Charité University Medicine, Berlin, Germany.
Department of Neurology, Charité University Medicine, Berlin, Germany.
Alzheimers Dement. 2015 Sep;11(9):1032-40. doi: 10.1016/j.jalz.2014.07.159. Epub 2014 Nov 20.
The long preclinical phase of Alzheimer's disease provides opportunities for potential disease-modifying interventions in prodromal stages such as mild cognitive impairment (MCI). Anodal transcranial direct current stimulation (anodal-tDCS), with its potential to enhance neuroplasticity, may allow improving cognition in MCI.
In a double-blind, cross-over, sham-controlled study, anodal-tDCS was administered to the left inferior frontal cortex during task-related and resting-state functional magnetic resonance imaging (fMRI) to assess its impact on cognition and brain functions in MCI.
During sham stimulation, MCI patients produced fewer correct semantic-word-retrieval responses than matched healthy controls, which was associated with hyperactivity in bilateral prefrontal regions. Anodal-tDCS significantly improved performance to the level of controls, reduced task-related prefrontal hyperactivity and resulted in "normalization" of abnormal network configuration during resting-state fMRI.
Anodal-tDCS exerts beneficial effects on cognition and brain functions in MCI, thereby providing a framework to test whether repeated stimulation sessions may yield sustained reversal of cognitive deficits.
阿尔茨海默病的漫长临床前阶段为在轻度认知障碍（MCI）等前驱期进行潜在的疾病修饰干预提供了机会。经颅直流电刺激（anodal-tDCS）具有增强神经可塑性的潜力，可能有助于改善 MCI 患者的认知能力。
在一项双盲、交叉、假刺激对照研究中，在与任务相关和静息状态功能磁共振成像（fMRI）期间对左侧额下回进行经颅直流电刺激（anodal-tDCS），以评估其对 MCI 患者认知和大脑功能的影响。
在假刺激期间，MCI 患者产生的正确语义词汇检索反应比匹配的健康对照组少，这与双侧前额叶区域的过度活跃有关。经颅直流电刺激（anodal-tDCS）显著改善了患者的表现，使其达到对照组的水平，减少了任务相关的前额叶过度活跃，并导致静息状态 fMRI 期间异常网络配置的“正常化”。
经颅直流电刺激（anodal-tDCS）对 MCI 患者的认知和大脑功能产生有益影响，从而为测试重复刺激疗程是否可以持续逆转认知缺陷提供了框架。
