Novozhenov V G, Viazitskiĭ P O, Ermakov E V, Kolomoets N M, Chekushin T I
Ter Arkh. 1989;61(3):84-7.
The patients with acute pneumonias demonstrated interdependent changes in lipid peroxidation (LPO), antioxidant system (AOS), immune system (IS), and in the pituitary-adrenocortical system (PAS), related to the character of the disease course. The most pronounced changes were seen in the patients with acute pneumonias eventuating in pneumofibrosis. The high level of LPO was combined with AOS depletion, immunodeficiency formation, and with dysfunction of the PAS. Antibacterial treatment did not exert any appreciable effect on the characteristics under study. Thus, the level of LPO and AOS status are important components in the pathogenesis of acute pneumonias, determining the character of the disease course and outcome. It is advisable that research work aimed at the design of the principles of antioxidant therapy may be intensified.
急性肺炎患者表现出脂质过氧化（LPO）、抗氧化系统（AOS）、免疫系统（IS）以及垂体 - 肾上腺皮质系统（PAS）的相互依存变化，这些变化与疾病进程的特征相关。在最终发展为肺纤维化的急性肺炎患者中观察到最明显的变化。高水平的LPO与AOS耗竭、免疫缺陷形成以及PAS功能障碍相关。抗菌治疗对所研究的特征没有产生任何明显影响。因此，LPO水平和AOS状态是急性肺炎发病机制中的重要组成部分，决定了疾病进程和结果的特征。建议加强旨在设计抗氧化治疗原则的研究工作。
