Novozhenov V G, Belonogov M A, Man'kov Iu U, Kolomoets N M, Teselkin Iu O, Popova N S
Klin Med (Mosk). 1995;73(3):40-4.
Lipid peroxidation (LPO) and antioxidant system (AOS) were investigated in 40 patients with chronic obstructive bronchitis (COB) in relation to clinical features of the disease. Bronchial tree inflammation was associated with reduced AOS function and intensification of LPO which reached a new high level. LPO activity, tocopherol concentration in red cell membranes and the severity of respiratory obstructive syndrome were correlated. It is suggested that high LPO activity may underlie the disease chronicity and development of progressive irreversible bronchial obstruction. Antioxidant drugs are believed necessary for COB patients not only in acute, but also in regression and remission phases of the disease.
对40例慢性阻塞性支气管炎（COB）患者的脂质过氧化（LPO）和抗氧化系统（AOS）进行了研究，并将其与该疾病的临床特征相关联。支气管树炎症与AOS功能降低和LPO增强相关，LPO达到了一个新的高水平。LPO活性、红细胞膜中生育酚浓度与呼吸阻塞综合征的严重程度相关。提示高LPO活性可能是该疾病慢性化及进行性不可逆支气管阻塞发展的基础。抗氧化药物被认为不仅对COB患者的急性期是必要的，而且在疾病的缓解期和消退期也是必要的。
