创伤性脑损伤患者疲劳的系统评价：过程、预测因素和后果。
A systematic review of fatigue in patients with traumatic brain injury: the course, predictors and consequences.
出版信息
Neurosci Biobehav Rev. 2014 Nov;47:684-716. doi: 10.1016/j.neubiorev.2014.10.024.
BACKGROUND
Fatigue is common after traumatic brain injury (TBI). Its risk factors, natural history and consequences are uncertain. Best-evidence synthesis was used to address the gaps.
METHODS
Five databases were searched for relevant peer-reviewed studies. Of the 33 articles appraised, 22 longitudinal studies were selected. Results were reported separately based on their timing of baseline assessment.
RESULTS
All studies document changes in fatigue frequency and severity with time, irrespective of setting or TBI severity. There is limited evidence for certain clinical and psychosocial variables as predictors of fatigue severity at follow-up. Early fatigue severity predicted persistent post-concussive symptoms and Glasgow outcome score at follow-up.
CONCLUSIONS
Fatigue is present before and immediately following injury, and can persist long term. The variation in findings supports the idea of fatigue in TBI as a nonhomogeneous entity, with different factors influencing the course of new onset or chronic fatigue. To decrease the heterogeneity, we emphasize the need for agreement on a core set of relevant fatigue predictors, definitions and outcome criteria. PROSPERO registry number: CRD42013004262.
背景
创伤性脑损伤（TBI）后常出现疲劳。其危险因素、自然病程和后果尚不确定。本研究采用最佳证据综合方法来解决这些问题。
方法
在五个数据库中搜索相关的同行评议研究。在评估的 33 篇文章中，选择了 22 项纵向研究。结果根据基线评估的时间点分别报告。
结果
所有研究都记录了随时间推移疲劳频率和严重程度的变化，无论设置或 TBI 严重程度如何。只有某些临床和心理社会变量的有限证据可以预测随访时的疲劳严重程度。早期疲劳严重程度预测了随访时持续存在的脑震荡后症状和格拉斯哥结局评分。
结论
疲劳在受伤前和受伤后立即出现，并可能长期存在。研究结果的差异支持 TBI 中疲劳是一种非同质实体的观点，不同的因素影响新发或慢性疲劳的病程。为了降低异质性，我们强调需要就一组核心相关疲劳预测因素、定义和结果标准达成一致。PROSPERO 注册号：CRD42013004262。
Zotero 插件