Hirose Tatiane E, Maluf Eliane M C P, Rodrigues Cristina O
Department of Pediatrics, Health Sciences Section, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.
Department of Internal Medicine, Health Sciences Section, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil; Discipline of Family Health, Maternal-Child Section, Universidade Positivo, Curitiba, PR, Brazil.
J Pediatr (Rio J). 2015 Mar-Apr;91(2):130-5. doi: 10.1016/j.jped.2014.07.002. Epub 2014 Oct 16.
To evaluate the possible effects of the introduction of the pneumococcal conjugate 10-valent vaccine schedule in the state of Parana on pneumococcal meningitis cases and to assess the distribution of serotypes among cases.
Cross-sectional study with retrospective data collection of cases of pneumococcal meningitis in the state of Paraná reported to Sistema de Informação de Agravos de Notificação (SINAN), from 1998 to 2011. A total of 1,339 cases of pneumococcal meningitis were analyzed; 1,205 cases from the pre-vaccine period (1998-2009) were compared to 134 cases from the post-vaccine period (2010-2011). Descriptive and comparative statistical analyses (chi-squared test and prevalence ratio) were performed using JMP 5.1.2 statistical software (JMP Statistical Discovery, North Carolina, USA) and EPI INFO 6 (Centers for Disease Control and Prevention, Georgia, EUA).
There was a significant reduction in the mean rates of incidence and mortality in the general population. The analysis of cases in the pre- and post-vaccination periods in the age groups covered by vaccination (younger than 2 years) showed significant reductions in incidence rates (6.01 cases/100,000 to 2.49 cases/100,000 individuals) and mortality (1.85 cases/100,000 population to 0.47 cases/100,000 population), while the mean lethality rate did not change significantly. There was a significant reduction in cases whose serotypes are included in the vaccine (80.7% to 53.3%).
Even after a short time of use, the 10-valent pneumococcal conjugate vaccine has already had a significant impact in reducing the incidence and mortality of meningitis cases among infants, as well as the reduction of cases whose serotypes are included in the vaccine.
评估在巴拉那州引入10价肺炎球菌结合疫苗接种计划对肺炎球菌性脑膜炎病例可能产生的影响，并评估病例中血清型的分布情况。
采用横断面研究，回顾性收集1998年至2011年向巴西法定传染病信息系统（SINAN）报告的巴拉那州肺炎球菌性脑膜炎病例数据。共分析了1339例肺炎球菌性脑膜炎病例；将疫苗接种前时期（1998 - 2009年）的1205例病例与疫苗接种后时期（2010 - 2011年）的134例病例进行比较。使用JMP 5.1.2统计软件（JMP Statistical Discovery，美国北卡罗来纳州）和EPI INFO 6（美国佐治亚州疾病控制与预防中心）进行描述性和比较性统计分析（卡方检验和患病率比）。
普通人群的发病率和死亡率平均显著降低。对疫苗接种覆盖年龄组（2岁以下）接种前和接种后时期的病例分析显示，发病率（从每10万人中6.01例降至每10万人中2.49例）和死亡率（从每10万人中1.85例降至每10万人中0.47例）均显著降低，而平均致死率无显著变化。疫苗中包含的血清型病例显著减少（从80.7%降至53.3%）。
即使在使用较短时间后，10价肺炎球菌结合疫苗已对降低婴儿脑膜炎病例的发病率和死亡率以及减少疫苗中包含血清型的病例产生了显著影响。
