Grando Indianara Maria, Moraes Camile de, Flannery Brendan, Ramalho Walter Massa, Horta Marco Aurélio P, Pinho Diana Lucia Moura, Nascimento Gilmara Lima
Cad Saude Publica. 2015 Feb;31(2):276-84. doi: 10.1590/0102-311x00169913.
The objective of this study was to analyze the impact of vaccination against Streptococcus pneumoniae on the morbidity and mortality from pneumococcal meningitis in children ≤ 2 years in Brazil, from 2007 to 2012. This is a descriptive study and ecological analysis using data from the Information System on Notifiable Diseases. Pre-vaccination (2007-2009) and post-vaccination (2011-2012) periods were defined to compare incidence rates and mortality. A total of 1,311 cases and 430 deaths were reported during the study period. Incidence decreased from 3.70/100,000 in 2007 to 1.84/100,000 in 2012, and mortality decreased from 1.30/100,000 to 0.40/100,000, or 50% and 69% respectively, with the greatest impact in the 6-11 month age group. This decrease in Pneumococcal meningitis morbidity and mortality rates two years after introduction of the 10-valent pneumococcal conjugate vaccine suggests its effectiveness.
本研究的目的是分析2007年至2012年期间，巴西针对2岁及以下儿童接种肺炎链球菌疫苗对肺炎球菌性脑膜炎发病率和死亡率的影响。这是一项描述性研究和生态分析，使用了法定传染病信息系统的数据。定义了疫苗接种前（2007 - 2009年）和疫苗接种后（2011 - 2012年）两个时期，以比较发病率和死亡率。研究期间共报告了1311例病例和430例死亡。发病率从2007年的3.70/10万降至2012年的1.84/10万，死亡率从1.30/10万降至0.40/10万，分别下降了50%和69%，对6 - 11个月龄组的影响最大。在引入10价肺炎球菌结合疫苗两年后，肺炎球菌性脑膜炎发病率和死亡率的下降表明了该疫苗的有效性。
