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光滑双脐螺中一类包含可变免疫球蛋白和凝集素结构域的分子家族。

A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata.

作者信息

Dheilly Nolwenn M, Duval David, Mouahid Gabriel, Emans Rémi, Allienne Jean-François, Galinier Richard, Genthon Clémence, Dubois Emeric, Du Pasquier Louis, Adema Coen M, Grunau Christoph, Mitta Guillaume, Gourbal Benjamin

机构信息

CNRS, UMR 5244, Ecologie et Evolution des Interactions (2EI), Perpignan F-66860, France; Université de Perpignan Via Domitia, Perpignan F-66860, France.

CNRS, UMR 5244, Ecologie et Evolution des Interactions (2EI), Perpignan F-66860, France; Université de Perpignan Via Domitia, Perpignan F-66860, France.

出版信息

Dev Comp Immunol. 2015 Jan;48(1):234-43. doi: 10.1016/j.dci.2014.10.009. Epub 2014 Oct 28.

DOI:10.1016/j.dci.2014.10.009
PMID:25451302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4255472/
Abstract

Technical limitations have hindered comprehensive studies of highly variable immune response molecules that are thought to have evolved due to pathogen-mediated selection such as fibrinogen-related proteins (FREPs) from Biomphalaria glabrata. FREPs combine upstream immunoglobulin superfamily (IgSF) domains with a C-terminal fibrinogen-related domain (FreD) and participate in reactions against trematode parasites. From RNAseq data we assembled a de novo reference transcriptome of B. glabrata to investigate the diversity of FREP transcripts. This study increased over two fold the number of bonafide FREP subfamilies and revealed important sequence diversity within FREP12 subfamily. We also report the discovery of related molecules that feature one or two IgSF domains associated with different C-terminal lectin domains, named C-type lectin-related proteins (CREPs) and Galectin-related protein (GREP). Together, the highly similar FREPs, CREPs and GREP were designated VIgL (Variable Immunoglobulin and Lectin domain containing molecules).

摘要

技术限制阻碍了对高度可变的免疫反应分子的全面研究，这些分子被认为是由于病原体介导的选择而进化的，例如来自光滑双脐螺的纤维蛋白原相关蛋白（FREPs）。FREPs将上游免疫球蛋白超家族（IgSF）结构域与C端纤维蛋白原相关结构域（FreD）结合，并参与针对吸虫寄生虫的反应。通过RNAseq数据，我们组装了光滑双脐螺的从头参考转录组，以研究FREP转录本的多样性。这项研究使真正的FREP亚家族数量增加了两倍多，并揭示了FREP12亚家族内重要的序列多样性。我们还报告了相关分子的发现，这些分子具有一个或两个与不同C端凝集素结构域相关的IgSF结构域，分别命名为C型凝集素相关蛋白（CREPs）和半乳糖凝集素相关蛋白（GREP）。高度相似的FREPs、CREPs和GREP统称为VIgL（含可变免疫球蛋白和凝集素结构域的分子）。