Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden.
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden.
Brain Behav Immun. 2015 Jan;43:198-204. doi: 10.1016/j.bbi.2014.10.001. Epub 2014 Oct 14.
Inflammation has been linked to the pathophysiology of bipolar disorder based on studies of inflammation markers, such as cytokine concentrations, in plasma and serum samples from cases and controls. However, peripheral measurements of cytokines do not readily translate to immunological activity in the brain. The aim of the present study was to study brain immune and inflammatory activity. To this end, we analyzed cytokines in cerebrospinal fluid from 121 euthymic bipolar disorder patients and 71 age and sex matched control subjects. Concentrations of 11 different cytokines were determined using immunoassays. Cerebrospinal fluid IL-8 concentrations were significantly higher in patients as compared to controls. The other cytokines measured were only detectable in part of the sample. IL-8 concentrations were positively associated to lithium- and antipsychotic treatment. The findings might reflect immune aberrations in bipolar disorder, or be due to the effects of medication.
炎症与双相情感障碍的病理生理学有关，这是基于对病例和对照的血浆和血清样本中的炎症标志物（如细胞因子浓度）的研究得出的。然而，细胞因子的外周测量并不能轻易转化为大脑中的免疫活性。本研究旨在研究大脑免疫和炎症活性。为此，我们分析了 121 名病情稳定的双相情感障碍患者和 71 名年龄和性别匹配的对照者的脑脊液中的细胞因子。使用免疫测定法测定了 11 种不同细胞因子的浓度。与对照组相比，患者的脑脊液 IL-8 浓度明显升高。其他测量的细胞因子仅部分样本中可检测到。IL-8 浓度与锂和抗精神病药物治疗呈正相关。这些发现可能反映了双相情感障碍中的免疫异常，或者是由于药物治疗的影响。
