• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Molecular subtyping of colorectal cancer: time to explore both intertumoral and intratumoral heterogeneity to evaluate patient outcome.结直肠癌的分子亚型分型：是时候探索肿瘤间和肿瘤内异质性以评估患者预后了。
Gastroenterology. 2015 Jan;148(1):10-3. doi: 10.1053/j.gastro.2014.11.024. Epub 2014 Nov 22.
2
BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features.近端结肠 BRAF 突变、微卫星稳定型腺癌：一种侵袭性腺癌，具有不良的生存预后、黏液分化和不良的形态学特征。
Am J Surg Pathol. 2012 May;36(5):744-52. doi: 10.1097/PAS.0b013e31824430d7.
3
Clinicopathologic and molecular characteristics of synchronous colorectal cancers: heterogeneity of clinical outcome depending on microsatellite instability status of individual tumors.同步结直肠癌的临床病理和分子特征：根据个体肿瘤的微卫星不稳定性状态，临床结局存在异质性。
Dis Colon Rectum. 2012 Feb;55(2):181-90. doi: 10.1097/DCR.0b013e31823c46ce.
4
Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes.分子标志物可识别与患者预后相关的III期结肠癌亚型。
Gastroenterology. 2015 Jan;148(1):88-99. doi: 10.1053/j.gastro.2014.09.041. Epub 2014 Oct 8.
5
CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels.结直肠癌中的CpG岛甲基化表型：新型与经典CpG岛甲基化表型标志物组合的比较
Arch Pathol Lab Med. 2008 Oct;132(10):1657-65. doi: 10.5858/2008-132-1657-CIMPIC.
6
Association between molecular subtypes of colorectal cancer and patient survival.结直肠癌分子亚型与患者生存率之间的关联。
Gastroenterology. 2015 Jan;148(1):77-87.e2. doi: 10.1053/j.gastro.2014.09.038. Epub 2014 Sep 30.
7
NO147: the Giving Tree.第147号：《爱心树》
J Natl Cancer Inst. 2014 Jun 12;106(7). doi: 10.1093/jnci/dju123. Print 2014 Jul.
8
KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients.中国结直肠癌患者的KRAS和BRAF基因突变及DNA错配修复状态
World J Gastroenterol. 2015 Feb 7;21(5):1595-605. doi: 10.3748/wjg.v21.i5.1595.
9
Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis.锯齿状肿瘤发生途径在炎症性肠病相关结直肠癌发生中的作用。
Oncol Rep. 2007 Nov;18(5):1093-7.
10
Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma.结直肠印戒细胞癌中的杂合性缺失、异常甲基化、BRAF 突变和 KRAS 突变。
Mod Pathol. 2012 Jul;25(7):1040-7. doi: 10.1038/modpathol.2012.44. Epub 2012 Apr 20.

引用本文的文献

1
Exploring Intratumoral Heterogeneity in Mixed Neuroendocrine-Nonneuroendocrine Neoplasms with Spatial Transcriptomics: Even More Diverse Than Anticipated.利用空间转录组学探索混合性神经内分泌-非神经内分泌肿瘤的瘤内异质性：比预期更加多样。
Endocr Pathol. 2025 Aug 20;36(1):29. doi: 10.1007/s12022-025-09869-w.
2
Features of combined gut bacteria and fungi from a Chinese cohort of colorectal cancer, colorectal adenoma, and post-operative patients.中国结直肠癌、结直肠腺瘤及术后患者队列中肠道细菌和真菌组合的特征
Front Microbiol. 2023 Aug 8;14:1236583. doi: 10.3389/fmicb.2023.1236583. eCollection 2023.
3
Anthelmintic Drugs as Emerging Immune Modulators in Cancer.抗蠕虫药物作为癌症治疗中的新兴免疫调节剂
Int J Mol Sci. 2023 Mar 29;24(7):6446. doi: 10.3390/ijms24076446.
4
Thymopentin-Mediated Inhibition of Cancer Stem Cell Stemness Enhances the Cytotoxic Effect of Oxaliplatin on Colon Cancer Cells.胸腺五肽介导的对癌症干细胞干性的抑制增强了奥沙利铂对结肠癌细胞的细胞毒性作用。
Front Pharmacol. 2022 Feb 15;13:779715. doi: 10.3389/fphar.2022.779715. eCollection 2022.
5
Molecular pathways in post-colonoscopy versus detected colorectal cancers: results from a nested case-control study.结肠镜检查后与检测到的结直肠癌的分子途径：巢式病例对照研究的结果。
Br J Cancer. 2022 Apr;126(6):865-873. doi: 10.1038/s41416-021-01619-z. Epub 2021 Dec 15.
6
Perspectives for circulating tumor DNA in clinical management of colorectal cancer.循环肿瘤DNA在结直肠癌临床管理中的前景
Int J Clin Oncol. 2021 Aug;26(8):1420-1430. doi: 10.1007/s10147-021-01937-5. Epub 2021 Jun 29.
7
Assaying Circulating-Tumor DNA To Predict Recurrence of Localized Colon Cancer.检测循环肿瘤DNA以预测局部结肠癌复发
Dig Med Res. 2020 Dec;3. doi: 10.21037/dmr.2020.04.02. Epub 2020 Dec 30.
8
Repositioning of Anthelmintic Drugs for the Treatment of Cancers of the Digestive System.抗蠕虫药物在消化系统癌症治疗中的再定位。
Int J Mol Sci. 2020 Jul 13;21(14):4957. doi: 10.3390/ijms21144957.
9
High predictability for identifying Lynch syndrome via microsatellite instability testing or immunohistochemistry in all Lynch-associated tumor types.通过微卫星不稳定性检测或免疫组织化学方法，在所有林奇综合征相关肿瘤类型中，对林奇综合征的识别具有高度可预测性。
Transl Cancer Res. 2019 Dec;8(Suppl 6):S559-S563. doi: 10.21037/tcr.2019.08.10.
10
Inflammation-Associated Microsatellite Alterations Caused by MSH3 Dysfunction Are Prevalent in Ulcerative Colitis and Increase With Neoplastic Advancement.MSH3 功能障碍引起的炎症相关微卫星改变在溃疡性结肠炎中普遍存在，并随着肿瘤的进展而增加。
Clin Transl Gastroenterol. 2019 Dec;10(12):e00105. doi: 10.14309/ctg.0000000000000105.

本文引用的文献

1
Molecular markers identify subtypes of stage III colon cancer associated with patient outcomes.分子标志物可识别与患者预后相关的III期结肠癌亚型。
Gastroenterology. 2015 Jan;148(1):88-99. doi: 10.1053/j.gastro.2014.09.041. Epub 2014 Oct 8.
2
Molecular markers for colon diagnosis, prognosis and targeted therapy.用于结肠癌诊断、预后评估及靶向治疗的分子标志物。
J Surg Oncol. 2015 Jan;111(1):96-102. doi: 10.1002/jso.23806. Epub 2014 Oct 8.
3
Association between molecular subtypes of colorectal cancer and patient survival.结直肠癌分子亚型与患者生存率之间的关联。
Gastroenterology. 2015 Jan;148(1):77-87.e2. doi: 10.1053/j.gastro.2014.09.038. Epub 2014 Sep 30.
4
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine.解析肿瘤内异质性和驱动事件的时间性获得以优化精准医学。
Genome Biol. 2014 Aug 27;15(8):453. doi: 10.1186/s13059-014-0453-8.
5
Detection of circulating tumor DNA in early- and late-stage human malignancies.早期和晚期人类恶性肿瘤中循环肿瘤DNA的检测
Sci Transl Med. 2014 Feb 19;6(224):224ra24. doi: 10.1126/scitranslmed.3007094.
6
Cancer genome landscapes.肿瘤基因组图谱。
Science. 2013 Mar 29;339(6127):1546-58. doi: 10.1126/science.1235122.
7
Recurrent R-spondin fusions in colon cancer.结直肠癌中 R-spondin 基因的反复融合。
Nature. 2012 Aug 30;488(7413):660-4. doi: 10.1038/nature11282.
8
Comprehensive molecular characterization of human colon and rectal cancer.全面的人类结肠和直肠癌分子特征分析。
Nature. 2012 Jul 18;487(7407):330-7. doi: 10.1038/nature11252.
9
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers.结直肠癌中针对 EGFR 阻断的获得性耐药的分子进化。
Nature. 2012 Jun 28;486(7404):537-40. doi: 10.1038/nature11219.
10
Genome-scale analysis of aberrant DNA methylation in colorectal cancer.结直肠癌中异常 DNA 甲基化的全基因组分析。
Genome Res. 2012 Feb;22(2):271-82. doi: 10.1101/gr.117523.110. Epub 2011 Jun 9.

Molecular subtyping of colorectal cancer: time to explore both intertumoral and intratumoral heterogeneity to evaluate patient outcome.

作者信息

Fearon Eric R, Carethers John M

机构信息

Division of Molecular Medicine and Genetics, Department of Internal Medicine and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan.

Division of Gastroenterology, Department of Internal Medicine and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan.

出版信息

Gastroenterology. 2015 Jan;148(1):10-3. doi: 10.1053/j.gastro.2014.11.024. Epub 2014 Nov 22.

DOI:10.1053/j.gastro.2014.11.024
PMID:25451650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4471844/
Abstract
摘要