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1
Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response.错配修复缺陷肿瘤的遗传多样性影响抗 PD-1 免疫治疗反应。
Science. 2019 May 3;364(6439):485-491. doi: 10.1126/science.aau0447.
2
Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.微卫星不稳定性与林奇综合征泛癌的存在相关。
J Clin Oncol. 2019 Feb 1;37(4):286-295. doi: 10.1200/JCO.18.00283. Epub 2018 Oct 30.
3
The colorectal cancer immune microenvironment and approach to immunotherapies.结直肠癌免疫微环境与免疫治疗方法
Future Oncol. 2017 Aug;13(18):1633-1647. doi: 10.2217/fon-2017-0145. Epub 2017 Aug 22.
4
Microsatellite Instability Pathway and EMAST in Colorectal Cancer.结直肠癌中的微卫星不稳定性通路与EMAST
Curr Colorectal Cancer Rep. 2017 Feb;13(1):73-80. doi: 10.1007/s11888-017-0352-y. Epub 2017 Feb 2.
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HEREDITARY, SPORADIC AND METASTATIC COLORECTAL CANCER ARE COMMONLY DRIVEN BY SPECIFIC SPECTRUMS OF DEFECTIVE DNA MISMATCH REPAIR COMPONENTS.遗传性、散发性和转移性结直肠癌通常由特定谱系的缺陷性DNA错配修复成分驱动。
Trans Am Clin Climatol Assoc. 2016;127:81-97.
6
A meta-analysis of MSI frequency and race in colorectal cancer.结直肠癌中微卫星不稳定性（MSI）频率与种族的荟萃分析。
Oncotarget. 2016 Apr 23;7(23):34546-57. doi: 10.18632/oncotarget.8945.
7
Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer.林奇综合征及林奇综合征模拟病症：遗传性结肠癌日益复杂的格局。
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8
Genetics and Genetic Testing in Hereditary Colorectal Cancer.遗传性结直肠癌的遗传学和基因检测。
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9
Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer.散发性结直肠癌中的遗传学与遗传生物标志物
Gastroenterology. 2015 Oct;149(5):1177-1190.e3. doi: 10.1053/j.gastro.2015.06.047. Epub 2015 Jul 26.
10
Molecular subtyping of colorectal cancer: time to explore both intertumoral and intratumoral heterogeneity to evaluate patient outcome.结直肠癌的分子亚型分型：是时候探索肿瘤间和肿瘤内异质性以评估患者预后了。
Gastroenterology. 2015 Jan;148(1):10-3. doi: 10.1053/j.gastro.2014.11.024. Epub 2014 Nov 22.

High predictability for identifying Lynch syndrome via microsatellite instability testing or immunohistochemistry in all Lynch-associated tumor types.

作者信息

Carethers John M

机构信息

Division of Gastroenterology, Department of Internal Medicine and Department of Human Genetics and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States.

出版信息

Transl Cancer Res. 2019 Dec;8(Suppl 6):S559-S563. doi: 10.21037/tcr.2019.08.10.

DOI:10.21037/tcr.2019.08.10
PMID:32266124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7138208/
Abstract
摘要