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PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study.载脂蛋白 L3 和跨膜 6 超家族成员 2 基因变异与巴基斯坦丙型肝炎慢性患者肝纤维化和肝硬化的关系:一项遗传关联研究。
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The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C.PNPLA3 和 TM6SF2 基因多态性在巴西慢性丙型肝炎患者肝纤维化和代谢异常中的作用。
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Nonalcoholic fatty liver disease and cardiovascular disease phenotypes.非酒精性脂肪性肝病与心血管疾病表型
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The Genetics of Clinical Liver Diseases: Insight into the E167K Variant.临床肝脏疾病的遗传学:对E167K变体的见解
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TM6SF2 rs58542926 impacts lipid processing in liver and small intestine.TM6SF2基因的rs58542926位点影响肝脏和小肠中的脂质代谢过程。
Hepatology. 2017 May;65(5):1526-1542. doi: 10.1002/hep.29021. Epub 2017 Mar 22.
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How Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?单基因啮齿动物模型对人类非酒精性脂肪性肝病研究有多大用处?
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Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice.肝跨膜6超家族成员2调节小鼠的胆固醇代谢。
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Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study.TM6SF2基因rs58542926位点在非酒精性小儿脂肪肝发病机制中的作用:一项多民族研究。
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Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study.基于前瞻性双胞胎研究的肝纤维化和脂肪变性的遗传性。
Gastroenterology. 2015 Dec;149(7):1784-93. doi: 10.1053/j.gastro.2015.08.011. Epub 2015 Aug 20.

本文引用的文献

1
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.TM6SF2基因的rs58542926位点影响非酒精性脂肪性肝病患者肝纤维化的进展。
Nat Commun. 2014 Jun 30;5:4309. doi: 10.1038/ncomms5309.
2
TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content.TM6SF2 是肝脏脂肪代谢的调节因子,影响甘油三酯的分泌和肝内脂滴含量。
Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8913-8. doi: 10.1073/pnas.1323785111. Epub 2014 Jun 4.
3
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.外显子组关联研究鉴定出一个 TM6SF2 变异,该变异赋予非酒精性脂肪性肝病易感性。
Nat Genet. 2014 Apr;46(4):352-6. doi: 10.1038/ng.2901. Epub 2014 Feb 16.

The TM6SF2 variants, novel genetic predictors for nonalcoholic steatohepatitis.

作者信息

Roh Yoon-Seok, Loomba Rohit, Seki Ekihiro

机构信息

Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California.

出版信息

Gastroenterology. 2015 Jan;148(1):252-4. doi: 10.1053/j.gastro.2014.11.014. Epub 2014 Nov 18.

DOI:10.1053/j.gastro.2014.11.014
PMID:25451657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4718074/
Abstract
摘要