哺乳动物下丘脑极地样洋地黄因子的存在。

Existence of a polar digitalis-like factor in mammalian hypothalamus.

作者信息

Goto A, Yamada K, Ishii M, Yoshioka M, Ishiguro T, Eguchi C, Sugimoto T

机构信息

Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.

出版信息

Biochem Biophys Res Commun. 1989 Jun 30;161(3):953-8. doi: 10.1016/0006-291x(89)91335-1.

DOI:10.1016/0006-291x(89)91335-1

PMID:2545202

Abstract

We were able to partially purify a polar digitalis-like factor from rat and bovine hypothalami based on the capacity to inhibit [3H]ouabain binding to intact human erythrocytes. This factor was characterized in reference to the digitalis-like factor that we have isolated and reported on. Hypothalamic factor shared digitalis-like activities and physicochemical properties with the one derived from human urine and mammalian plasma. These findings strongly suggest that a polar digitalis-like factor identical to the circulatory factor does exist in mammalian hypothalamus.

摘要

基于抑制[3H]哇巴因与完整人红细胞结合的能力，我们能够从大鼠和牛的下丘脑部分纯化出一种极性类洋地黄因子。该因子是参照我们已分离并报道的类洋地黄因子来进行表征的。下丘脑因子与源自人尿液和哺乳动物血浆的因子具有类洋地黄活性和物理化学性质。这些发现有力地表明，哺乳动物下丘脑确实存在一种与循环因子相同的极性类洋地黄因子。