Guitar Nicole A, Roberts William A
Department of Psychology, Western University, London, Ontario N6A 5C2, Canada.
Department of Psychology, Western University, London, Ontario N6A 5C2, Canada.
Behav Processes. 2015 Mar;112:100-7. doi: 10.1016/j.beproc.2014.10.007. Epub 2014 Nov 21.
The interaction of reference and working memory was studied in rats on an eight-arm radial maze. Each trial involved a two-phase procedure in which a rat was forced to enter four arms on the maze in a study phase and then was allowed to choose among all eight arms in a test phase given 5-s later, with choice of only the previously unvisited arms rewarded. For each rat, two arms on the maze were designated as reference memory arms because they were never entered in the study phase and were always rewarded in the test phase. The other two arms never entered in the study phase and rewarded in the test phase were working memory arms and varied randomly from trial to trial. In Experiment 1, rats showed acquisition of equivalent preference for entering the reference and working memory arms in their first four choices of the test phase. Subsequent tests carried out in Experiment 2 compared performance at 5-s, 1-h, and 24-h retention intervals when reference memory and working memory were congruent and incongruent. Higher accuracy for choice of reference memory arms than working memory arms appeared at the 1-h and 24-h retention intervals on congruent tests but not on incongruent tests. A process dissociation procedure analysis indicated that working memory but not reference memory declined over the 24-h retention interval. The interaction of working and reference memory was shown by superior choice of reference memory arms on congruent tests than on incongruent tests at 1-h and 24-h retention intervals but not at the 5-s retention interval. These findings suggest that working and reference memory are independent systems that can facilitate and compete with one another. This article is part of a Special Issue entitled: Tribute to Tom Zentall.
在八臂放射状迷宫中对大鼠的参照记忆与工作记忆的相互作用进行了研究。每次试验包含一个两阶段程序，在学习阶段，一只大鼠被强制进入迷宫的四个臂，然后在5秒后进入测试阶段，此时允许大鼠在所有八个臂中进行选择，只有选择之前未进入过的臂才会得到奖励。对于每只大鼠，迷宫中的两个臂被指定为参照记忆臂，因为它们在学习阶段从未被进入过，并且在测试阶段总是会得到奖励。另外两个在学习阶段从未被进入过且在测试阶段得到奖励的臂是工作记忆臂，并且每次试验中随机变化。在实验1中，大鼠在测试阶段的前四次选择中，对进入参照记忆臂和工作记忆臂表现出同等的偏好习得。在实验2中进行的后续测试比较了在参照记忆和工作记忆一致及不一致时，在5秒、1小时和24小时的保持间隔下的表现。在一致测试中，在1小时和24小时保持间隔时，选择参照记忆臂的准确性高于工作记忆臂，但在不一致测试中并非如此。过程分离程序分析表明，在24小时保持间隔内，工作记忆而非参照记忆有所下降。在1小时和24小时保持间隔时，一致测试中参照记忆臂的选择优于不一致测试，而在5秒保持间隔时并非如此，这表明了工作记忆与参照记忆的相互作用。这些发现表明，工作记忆和参照记忆是相互独立的系统，它们既可以相互促进，也可以相互竞争。本文是名为：向汤姆·曾塔尔致敬的特刊的一部分。
