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突触间隙处的甘氨酸门控突触后膜发放抑制。

Glycine gated spiking inhibitory postsynaptic membrane at the synaptic cleft.

作者信息

Deka Krisha M, Roy Soumik

机构信息

Department of Electronics and Communication Engineering, Tezpur University, Napaam Post, Tezpur, Assam -784028.

出版信息

Ann Neurosci. 2014 Oct;21(4):134-7. doi: 10.5214/ans.0972.7531.210404.

DOI:10.5214/ans.0972.7531.210404
PMID:25452673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4248464/
Abstract

BACKGROUND

Enzyme modified field effect transistor (ENFET) may be used to represent the variable conductance of transmitter-gated ion channels in the postsynaptic region of the neuron.

PURPOSE

The objective of this work is to develop a simple analog circuit model that can simulate the function of neurotransmitter glycine gated ion channels of postsynaptic membrane at the synaptic cleft.

METHODS

In this paper, Glycine sensitive ENFET is incorporated into the Hodgkin-Huxley (H-H) circuit model of the postsynaptic membrane at the synaptic cleft.

RESULTS

Simulation of the circuit model yields an output representing the membrane potential of the synaptic region. Simulation is performed in MATLAB environment for inhibitory action of synapses.

CONCLUSION

This model can be used in neuro-bioengineering fields for simulation of binding activity and electrical activity of the postsynaptic region.

摘要

背景

酶修饰场效应晶体管（ENFET）可用于表示神经元突触后区域中递质门控离子通道的可变电导。

目的

本工作的目标是开发一个简单的模拟电路模型，该模型能够模拟突触间隙处突触后膜神经递质甘氨酸门控离子通道的功能。

方法

本文将甘氨酸敏感型ENFET纳入突触间隙处突触后膜的霍奇金-赫胥黎（H-H）电路模型。

结果

该电路模型的模拟产生了一个代表突触区域膜电位的输出。在MATLAB环境中对突触的抑制作用进行了模拟。

结论

该模型可用于神经生物工程领域，以模拟突触后区域的结合活性和电活动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/dd5717cc1b2d/ANS0972-7531-21-134-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/92d443a41de8/ANS0972-7531-21-134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/500835351a70/ANS0972-7531-21-134-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/0681ee6c9a03/ANS0972-7531-21-134-e001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/bdcf983b593b/ANS0972-7531-21-134-e002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/9b23f9738c4d/ANS0972-7531-21-134-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/fba2c88be817/ANS0972-7531-21-134-e003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/20e60ae68ab6/ANS0972-7531-21-134-e004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/fa00fbde7bc7/ANS0972-7531-21-134-e005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/d345db01a20c/ANS0972-7531-21-134-e006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/8e93505ee57f/ANS0972-7531-21-134-e007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/376bbc3e549e/ANS0972-7531-21-134-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/9c2376b26b1c/ANS0972-7531-21-134-e008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/dd5717cc1b2d/ANS0972-7531-21-134-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/92d443a41de8/ANS0972-7531-21-134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/500835351a70/ANS0972-7531-21-134-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/0681ee6c9a03/ANS0972-7531-21-134-e001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/bdcf983b593b/ANS0972-7531-21-134-e002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/9b23f9738c4d/ANS0972-7531-21-134-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/fba2c88be817/ANS0972-7531-21-134-e003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/20e60ae68ab6/ANS0972-7531-21-134-e004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/fa00fbde7bc7/ANS0972-7531-21-134-e005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/d345db01a20c/ANS0972-7531-21-134-e006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/8e93505ee57f/ANS0972-7531-21-134-e007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/376bbc3e549e/ANS0972-7531-21-134-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/9c2376b26b1c/ANS0972-7531-21-134-e008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e0e/4248464/dd5717cc1b2d/ANS0972-7531-21-134-g005.jpg

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本文引用的文献

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2
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Ann Neurosci. 2013 Oct;20(4):145-8. doi: 10.5214/ans.0972.7531.200405.
3
CC chemokine receptor-3 as new target for age-related macular degeneration.CC 趋化因子受体-3 作为与年龄相关的黄斑变性的新靶点。
Gene. 2013 Jul 1;523(1):106-11. doi: 10.1016/j.gene.2013.03.052. Epub 2013 Apr 6.
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Single nucleotide polymorphisms in MCP-1 and its receptor are associated with the risk of age related macular degeneration.单核细胞趋化蛋白-1 及其受体的单核苷酸多态性与年龄相关性黄斑变性的风险相关。
PLoS One. 2012;7(11):e49905. doi: 10.1371/journal.pone.0049905. Epub 2012 Nov 21.
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Single nucleotide polymorphism and serum levels of VEGFR2 are associated with age related macular degeneration.单核苷酸多态性和血管内皮生长因子受体 2 的血清水平与年龄相关性黄斑变性有关。
Curr Neurovasc Res. 2012 Nov;9(4):256-65. doi: 10.2174/156720212803530681.
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