Anton R F, Ballenger J C, Lydiard R B, Laraia M T, Howell E F, Gold P W
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425.
Biol Psychiatry. 1989 Jul;26(3):257-64. doi: 10.1016/0006-3223(89)90038-3.
Prostaglandins are thought to act as neuromodulators of both central catecholamine and endocrine systems. Abnormalities of these systems have been described in affective disorders, in general, and in agoraphobia with panic attacks, in particular. This study measured basal prostaglandin-E (PGE) cerebrospinal fluid (CSF) levels in 20 patients with agoraphobia with panic attacks and 10 nonpsychiatric controls. In a subgroup of patients and controls, CSF levels of adrenocorticotrophic hormone (ACTH) and corticotropin-releasing factor (CRF) were also measured. There was no significant difference in CSF PGE levels between patients and controls. However, patients with higher depression scores had lower CSF PGE levels. CSF PGE levels tended to correlate with CSF ACTH, but not CSF CRF in the patient group, in general, and in the female patients, in particular. These findings do not support an abnormality in basal CNS PGE production in agoraphobia with panic attacks, but suggest further study of the PGE modulatory effect on the hypothalamic-pituitary-adrenal axis in this disorder.
前列腺素被认为是中枢儿茶酚胺系统和内分泌系统的神经调质。一般来说，这些系统的异常在情感障碍中已有描述，尤其是在伴有惊恐发作的广场恐惧症中。本研究测量了20例伴有惊恐发作的广场恐惧症患者和10名非精神科对照者的基础前列腺素-E（PGE）脑脊液（CSF）水平。在患者和对照者的一个亚组中，还测量了脑脊液促肾上腺皮质激素（ACTH）和促肾上腺皮质激素释放因子（CRF）水平。患者和对照者的脑脊液PGE水平无显著差异。然而，抑郁评分较高的患者脑脊液PGE水平较低。总体而言，尤其是在女性患者中，患者组的脑脊液PGE水平倾向于与脑脊液ACTH相关，但与脑脊液CRF无关。这些发现不支持伴有惊恐发作的广场恐惧症患者中枢神经系统基础PGE产生存在异常，但提示需要进一步研究PGE对该疾病下丘脑-垂体-肾上腺轴的调节作用。
