Augustine Dominic, Sekar Bala, Thiruneervannan R, Sundhar Murali, Reddy Donga Vijay Kumar, Patil Shankar Gouda
Department of Oral and Maxillofacial Pathology, Bangalore Institute of Dental Sciences and Hospital, Lakkasandra, Bangalore, India.
Department of Oral and Maxillofacial Pathology, Vinayaka Missions Sankarachariyar Dental College and Hospital, Ariyanoor, Salem, Tamil Nadu, India.
J Int Soc Prev Community Dent. 2014 Nov;4(Suppl 1):S68-71. doi: 10.4103/2231-0762.144603.
Non-Hodgkin's lymphoma (NHL) is a group of highly diverse malignancies whose prognosis depends on the histologic type and associated factors like HIV positivity.
The aim of this study was to evaluate eight cases of NHL for their histologic type and HIV positivity, since both are major prognostic factors for NHL.
Eight cases of primary NHL of the oral cavity were evaluated for age, sex, clinical presentation, and the histologic type, along with immunohistochemistry. These cases were also evaluated for HIV positivity.
NHL cases which were diagnosed through the dental OPD and subsequent biopsy procedure were chosen. The patient data, including age, sex, location, clinical presentation, radiographic presentation, metastasis, and histologic subtype, according to the World Health Organization (WHO) classification were tabulated. Immunohistochemical markers were used to confirm the cell type. CD20 and CD3 were used for B cell and T cell, respectively. Subsequent western blot analysis was carried out for HIV detection.
75% of the NHL was of B-cell type; of this, 83% was found to be diffuse large B-cell lymphoma, which is an aggressive variant. 62.5% of cases were found to be HIV positive.
This study emphasizes the need for HIV investigation in NHL cases and the need to determine the histologic type, both of which significantly affect the treatment outcome and prognosis.
非霍奇金淋巴瘤（NHL）是一组高度异质性的恶性肿瘤，其预后取决于组织学类型以及诸如HIV阳性等相关因素。
本研究旨在评估8例NHL患者的组织学类型和HIV阳性情况，因为这两者都是NHL的主要预后因素。
对8例口腔原发性NHL患者进行年龄、性别、临床表现、组织学类型评估，并进行免疫组化检测。同时对这些病例进行HIV阳性评估。
选取通过牙科门诊及后续活检程序确诊的NHL病例。将患者数据，包括年龄、性别、部位、临床表现、影像学表现、转移情况以及根据世界卫生组织（WHO）分类的组织学亚型制成表格。使用免疫组化标记物来确认细胞类型。CD20和CD3分别用于B细胞和T细胞。随后进行western blot分析以检测HIV。
75%的NHL为B细胞型；其中，83%为弥漫性大B细胞淋巴瘤，这是一种侵袭性亚型。62.5%的病例被发现HIV呈阳性。
本研究强调了对NHL病例进行HIV检测的必要性以及确定组织学类型的必要性，这两者均会显著影响治疗结果和预后。
