de Rekeneire Nathalie, Volpato Stefano
Section of Geriatrics, Department of Internal Medicine, Yale School of Medicine, 367 Cedar Street, Harkness Building A, Room 317A, New Haven, CT 06520, USA.
Section of Internal Medicine, Gerontology and Clinical, Nutrition, Department of Medical Sciences, Azienda Ospedaliero-Universitaria di Ferrara U.O. Medicina Interna Universitaria, University of Ferrara, Via Aldo Moro 8, 1B1 Stanza 1.35.30, Ferrara 44124, Italy.
Clin Geriatr Med. 2015 Feb;31(1):51-65, viii. doi: 10.1016/j.cger.2014.08.018. Epub 2014 Nov 15.
Functional decline and physical disability are an important clinical and public health problem in older adults because they are associated with loss of independence, nursing home admission, and mortality. Several impairments and comorbidities related to or associated with diabetes are potential disabling conditions that could account for the excess risk of disability. But in most studies, no single condition explains this association. Accelerated loss of muscle strength is a potential mediator in the disabling effect of diabetes. Because some diabetes-related comorbidities are potential modifiable risk factors, preventing and reducing the excess risk of disability associated with diabetes needs further study.
功能衰退和身体残疾是老年人重要的临床和公共卫生问题，因为它们与失去独立生活能力、入住疗养院及死亡率相关。一些与糖尿病相关或伴发的损伤和共病是潜在的致残状况，可能导致残疾风险增加。但在大多数研究中，没有单一因素能解释这种关联。肌肉力量加速丧失是糖尿病致残效应的一个潜在中介因素。由于一些与糖尿病相关的共病是潜在的可改变风险因素，预防和降低与糖尿病相关的额外残疾风险还需要进一步研究。
