Landor Michael, Benami Ari, Segev Nitzan, Loberant Beth
1 Department of Medicine, Albert Einstein College of Medicine , New York, New York, USA .
J Med Food. 2015 Feb;18(2):250-8. doi: 10.1089/jmf.2013.0178. Epub 2014 Dec 2.
Species of Hoodia Sweet ex Decne., family Apocynaceae, a southern African succulent plant, have been recognized for their appetite suppressing properties. Products that support appetite and weight control have been developed in Israel from locally cultivated Hoodia spp. To study consumer acceptance, efficacy of, and tolerance for a frozen product based on whole aerial parts of Hoodia parviflora N.E. Br., we initiated and conducted this single-blind, randomized, placebo-controlled consumer trial. Volunteer participants ingested flavored 3 g frozen Hoodia or placebo cubes for 40 days. Subjects were weighed and measured and baseline body-mass index was determined. Adverse events were monitored and eight mild, transient, possible treatment-emergent events were reported. No moderate, severe, or chronic events were reported. On days 1, 10, and 40, subjects self-reported their perceptions of food consumption, hunger development, incidence and control of food cravings, and efficacy of the product. On day 40, the treatment group demonstrated a statistically significant decrease in measured quantitative parameters against the placebo and reported a positive perception of the product.
丽杯角属植物（Hoodia Sweet ex Decne.），夹竹桃科，一种南非多肉植物，因其抑制食欲的特性而闻名。以色列利用当地种植的丽杯角属植物开发了支持食欲和体重控制的产品。为了研究消费者对基于小花丽杯角（Hoodia parviflora N.E. Br.）全地上部分的冷冻产品的接受度、功效和耐受性，我们启动并开展了这项单盲、随机、安慰剂对照的消费者试验。志愿者参与者食用调味的3克冷冻丽杯角或安慰剂方块，持续40天。对受试者进行称重和测量，并确定基线体重指数。监测不良事件，报告了8起轻微、短暂、可能由治疗引起的事件。未报告中度、重度或慢性事件。在第1天、第10天和第40天，受试者自行报告他们对食物摄入、饥饿感发展、食物渴望的发生率和控制情况以及产品功效的看法。在第40天，治疗组相对于安慰剂在测量的定量参数上显示出统计学上的显著下降，并对产品给予了积极评价。
