Kulik Laura M, Chokechanachaisakul Attasit
Kovler Organ Transplantation Center, NMH, Arkes Family Pavilion, Suite 1900, 676 North Saint Clair, Chicago, IL 60611, USA.
Kovler Organ Transplantation Center, NMH, Arkes Family Pavilion, Suite 1900, 676 North Saint Clair, Chicago, IL 60611, USA.
Clin Liver Dis. 2015 Feb;19(1):23-43. doi: 10.1016/j.cld.2014.09.002. Epub 2014 Oct 30.
The burden of hepatocellular carcinoma is rising and anticipated to escalate and while the best chance for long term cure remains transplantation, however the shortage of available organs remains a limitation. Liver directed therapy can serve the role of bridge/downstaging to transplant or as palliative care. Despite an improved overall survival among patients with HCC, due to advancements in surgical techniques, liver directed and systemic therapy, the 5 year overall survival remains low at 18% high-lightening the need for novel therapies. Surveillance for HCC is key to detect disease at an early stage to increase the chances for a potentially curative option.
肝细胞癌的负担正在上升，预计还会加剧。虽然长期治愈的最佳机会仍然是肝移植，但可用器官的短缺仍是一个限制因素。肝导向治疗可起到作为移植的桥梁/降期治疗或作为姑息治疗的作用。尽管由于手术技术、肝导向治疗和全身治疗的进步，肝癌患者的总体生存率有所提高，但5年总生存率仍低至18%，这凸显了对新型治疗方法的需求。肝癌监测是在早期阶段发现疾病以增加潜在治愈选择机会的关键。
