Department of General Surgery, Hefei Second People's Hospital, Anhui Medical University, Hefei 230011, Anhui, China.
Department of Electrocardiogram Diagnosis, The Second Affiliated Hospital, Anhui Medical University, Hefei 230060, Anhui, China.
Biosci Rep. 2019 May 10;39(5). doi: 10.1042/BSR20181991. Print 2019 May 31.
Human leucocyte antigen-G (HLA-G) plays an important role in the progression of human cancers. A growing number of published studies have investigated the correlation between the 3' untranslated region (3'UTR) 14-bp insertion/deletion () polymorphism and the associated cancer risk in different populations. However, results from previous studies are inconclusive and inconsistent for the different type of cancers. Therefore, we undertook a meta-analysis to assess the effects of the 14-bp polymorphism on cancer risk. A systematic literature search was conducted in PubMed, Web of Science, CNKI, VIP, and Wanfang databases to obtain relevant studies up to 28 January 2019. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used. Twenty-five published case-control studies comprising 4981 cases and 6391 controls were included in the current meta-analysis. The results of the overall analysis revealed that the 14-bp genotype and allele were associated with the total cancer risk in the homozygote comparison model (: OR = 0.80, CI = 0.64-1.00; =0.049) and the allelic comparison model (: OR = 0.89, CI = 0.81-0.99; =0.035), with a protective role. Further subgroup analyses indicated that the 14-bp polymorphism was associated with the risk of breast cancer and oesophageal cancer (EC), and significant risk of cancer was also observed in Mixed populations and population-based (PB). The results of our meta-analysis show that the 14-bp polymorphism plays an important role in cancer risk, particularly in breast cancer and esophageal cancer in Mixed populations. Additional case-control studies with different types of cancer spanning different ethnicities are needed to extend the present findings.
人类白细胞抗原-G（HLA-G）在人类癌症的进展中起着重要作用。越来越多的已发表研究调查了 3'非翻译区（3'UTR）14 位核苷酸插入/缺失（）多态性与不同人群相关癌症风险之间的相关性。然而，由于不同类型癌症的研究结果不一致，先前的研究结果尚无定论。因此，我们进行了荟萃分析以评估 14 位核苷酸多态性对癌症风险的影响。在 PubMed、Web of Science、CNKI、VIP 和万方数据库中进行了系统的文献检索，以获取截至 2019 年 1 月 28 日的相关研究。使用合并的优势比（OR）和相应的 95％置信区间（CI）。目前的荟萃分析共纳入了 25 项已发表的病例对照研究，包括 4981 例病例和 6391 例对照。总体分析的结果表明，在纯合子比较模型（：OR = 0.80，CI = 0.64-1.00；=0.049）和等位基因比较模型（：OR = 0.89，CI = 0.81-0.99；=0.035）中，14 位核苷酸基因型和等位基因与总癌症风险相关，具有保护作用。进一步的亚组分析表明，14 位核苷酸多态性与乳腺癌和食管癌（EC）的风险相关，在混合人群和基于人群（PB）中也观察到显著的癌症风险。本荟萃分析的结果表明，14 位核苷酸多态性在癌症风险中起重要作用，尤其是在混合人群中的乳腺癌和食管癌。需要进行不同类型癌症和不同种族的病例对照研究，以扩展目前的研究结果。
