Kim S K, Jeong K H, Kang I J, Chung J H, Shin M K, Lee M H
Kohwang Medical Research Institute and Department of Pharmacology, College of Medicine, Kyung Hee University, Seoul, Korea.
Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
Genet Mol Res. 2015 Dec 3;14(4):15839-47. doi: 10.4238/2015.December.1.35.
Numerous studies have investigated the potential relationship between the human leukocyte antigen (HLA)-G 14-bp insertion/deletion (INS/DEL) polymorphisms and autoimmune disease (AID). However, published results are inconclusive. Our aim was to determine whether the 14-bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. A systemic literature search of the PubMed and EMBASE databases was conducted to identify eligible studies investigating the association of the HLA-G 14-bp INS/DEL polymorphism with AID. Our analysis included 11 publications involving a total of 6462 individuals. Overall, no significant association between the HLA-G 14-bp INS/DEL polymorphism and AID was detected in any comparison model. Further subgroup analyses based on AID types and ethnicity also revealed no significant associations. Our results suggest that the HLA-G 14-bp INS/DEL polymorphism is unrelated to the development of AID. Further studies including larger sample sizes are warranted to confirm these results.
众多研究调查了人类白细胞抗原（HLA）-G基因14碱基对插入/缺失（INS/DEL）多态性与自身免疫性疾病（AID）之间的潜在关系。然而，已发表的结果尚无定论。我们的目的是确定HLA-G基因中的14碱基对INS/DEL多态性是否会增加患AID的风险。我们对PubMed和EMBASE数据库进行了系统的文献检索，以找出研究HLA-G基因14碱基对INS/DEL多态性与AID关联的合格研究。我们的分析纳入了11篇文献，共涉及6462名个体。总体而言，在任何比较模型中均未检测到HLA-G基因14碱基对INS/DEL多态性与AID之间存在显著关联。基于AID类型和种族的进一步亚组分析也未发现显著关联。我们的结果表明，HLA-G基因14碱基对INS/DEL多态性与AID的发生无关。需要开展包括更大样本量的进一步研究来证实这些结果。
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