Roberts Rosebud O, Boardman Lisa A, Cha Ruth H, Pankratz V Shane, Johnson Ruth A, Druliner Brooke R, Christianson Teresa J H, Roberts Lewis R, Petersen Ronald C
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, United States; Department of Neurology, Mayo Clinic, Rochester, MN 55905, United States.
Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
Mech Ageing Dev. 2014 Nov-Dec;141-142:64-9. doi: 10.1016/j.mad.2014.10.002. Epub 2014 Oct 22.
Peripheral blood telomere length has been associated with age-related conditions including Alzheimer's disease (AD). This suggests that telomere length may identify subjects at increased risk of AD. Thus, we investigated the associations of peripheral blood telomere length with amnestic mild cognitive impairment (aMCI), a putative precursor of AD, among Mayo Clinic Study of Aging participants who were prospectively followed for incident aMCI. We matched 137 incident aMCI cases (mean age 81.1 years, [range 70.9-90.8]; 49.6% men) by age and sex to 137 cognitively normal controls. We measured telomere length (T/S ratio) at baseline using quantitative PCR. Compared to the middle T/S quintile (Q3), the risk of aMCI was elevated for subjects with the shortest (Q1: HR, 2.85, 95% Confidence interval [CI] 0.98, 8.25; p=0.05) and the longest telomere lengths (Q5: HR, 5.58, 95%CI, 2.21, 14.11; p=0.0003). In this elderly cohort, short and long telomeres were associated with increased risk of aMCI. Our findings suggest that both long and short telomere lengths may play a role in the pathogenesis of aMCI, and may be markers of increased risk of aMCI.
外周血端粒长度与包括阿尔茨海默病（AD）在内的年龄相关疾病有关。这表明端粒长度可能识别出患AD风险增加的个体。因此，我们在梅奥诊所衰老研究的参与者中，对发生遗忘型轻度认知障碍（aMCI）（AD的一种假定前驱症状）的情况进行了前瞻性随访，调查了外周血端粒长度与aMCI之间的关联。我们按照年龄和性别将137例aMCI发病病例（平均年龄81.1岁，[范围70.9 - 90.8]；49.6%为男性）与137名认知正常的对照者进行匹配。我们在基线时使用定量PCR测量端粒长度（T/S比值）。与T/S比值处于中间五分位数（Q3）相比，端粒长度最短（Q1：风险比[HR]，2.85，95%置信区间[CI] 0.98，8.25；p = 0.05）和最长（Q5：HR，5.58，95%CI，2.21，14.11；p = 0.0003）的受试者发生aMCI的风险升高。在这个老年队列中，端粒长短均与aMCI风险增加有关。我们的研究结果表明，端粒长度无论长短可能在aMCI的发病机制中都起作用，并且可能是aMCI风险增加的标志物。
