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端粒长度与衰老相关疾病之间的关系。

The relationship between telomere length and aging-related diseases.

作者信息

Huang Xuanqi, Huang Leyi, Lu Jiaweng, Cheng Lijuan, Wu Du, Li Linmeng, Zhang Shuting, Lai Xinyue, Xu Lu

机构信息

Hangzhou Normal University School of Nursing, Hangzhou, China.

Hangzhou Normal University School of Basic Medical Sciences, Hangzhou, China.

出版信息

Clin Exp Med. 2025 Mar 5;25(1):72. doi: 10.1007/s10238-025-01608-z.

Abstract

The intensifying global phenomenon of an aging population has spurred a heightened emphasis on studies on aging and disorders associated with aging. Cellular senescence and aging are known to be caused by telomere shortening. Telomere length (TL) has emerged as a biomarker under intense scrutiny, and its widespread use in investigations of diseases tied to advancing age. This review summarizes the current knowledge of the association between telomeres and aging-related diseases, explores the important contribution of dysfunctional telomeres to the development and progression of these diseases, and aims to provide valuable insights for the development of novel therapeutic strategies.

摘要

全球人口老龄化现象日益加剧,这促使人们更加重视对衰老及与衰老相关疾病的研究。已知细胞衰老和老化是由端粒缩短引起的。端粒长度(TL)已成为备受严格审查的生物标志物,并在与年龄增长相关疾病的研究中得到广泛应用。本综述总结了目前关于端粒与衰老相关疾病之间关联的知识,探讨了功能失调的端粒对这些疾病发生和发展的重要作用,旨在为开发新的治疗策略提供有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4d8/11882723/01873e972016/10238_2025_1608_Fig1_HTML.jpg

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