Zaina Sara, Mastrangelo Giuseppe, Ballarin Maria Nicoletta, Scoizzato Luca, Carradori Giorgio, Fedeli Ugo, Capella Silvana, Belluso Elena
a Unit of Occupational Medicine, Department of Cardiac, Thoracic, and Vascular Sciences , University of Padua , Padua , Italy.
b Health and Safety at Work Department (SPSAL) , Local Health Authority No. 12, Veneto Region, Mestre - Venice , Italy.
Arch Environ Occup Health. 2016 May 3;71(3):129-35. doi: 10.1080/19338244.2014.988675. Epub 2014 Dec 2.
To assess the validity of the procedure as a test of asbestos exposure, we compared urinary asbestos fibers with occupational and environmental exposure data in a random sample of 48 subjects with high past asbestos exposure. Occupational and environmental exposure was estimated on questionnaire, pleural plaques were diagnosed with computed tomography, and inorganic fibers and particles were identified by scanning electron microscope with an energy-dispersive spectrometry. Few urinary asbestos fibers (in 15% of workers and 17% of cases with pleural plaques) and high amount of urinary silicate (particularly nonfibrous particles) were detected. Asbestos undergoes dissolution in lung tissues, but the secondary minerals are largely unknown. These materials, possibly nonfibrous silicates or metals, could be excreted with urine. Therefore, another study including a control group is warranted to discriminate the occupational origin of minerals in the urine.
为评估该检测程序作为石棉暴露检测方法的有效性，我们在48名既往石棉暴露量较高的受试者随机样本中，将尿中石棉纤维与职业和环境暴露数据进行了比较。职业和环境暴露通过问卷调查进行评估，胸膜斑通过计算机断层扫描诊断，无机纤维和颗粒通过配备能谱仪的扫描电子显微镜进行识别。检测到尿中石棉纤维含量较少（15%的工人和17%有胸膜斑的病例），而尿中硅酸盐含量较高（特别是非纤维颗粒）。石棉在肺组织中会发生溶解，但其次生矿物大多未知。这些物质可能是非纤维硅酸盐或金属，可随尿液排出。因此，有必要开展另一项纳入对照组的研究，以区分尿液中矿物质的职业来源。
