Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.
Brain Pathol. 2013 May;23(3):350-7. doi: 10.1111/bpa.12046.
Parkinson's disease is characterized by α-synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α-synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α-synuclein can transfer from cell to cell. In this review, we highlight the involvement of α-synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of α-synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons.
帕金森病的特征是路易体和路易神经纤维形式的α-突触核蛋白病理学。Braak 等人描述了帕金森病中α-突触核蛋白病理学的空间和时间传播。最近的实验研究表明，α-突触核蛋白可以在细胞间转移。在这篇综述中，我们强调了α-突触核蛋白在帕金森病和 Braak 帕金森病病理学分期中的作用。我们讨论了α-突触核蛋白传播是否类似于朊病毒的机制可能导致帕金森病病理学。我们描述了最近关于α-突触核蛋白细胞间转移的研究，并重点关注α-突触核蛋白沿着神经元的长距离轴突运输。
