Department of Endocrinology, Yale University School of Medicine, New Haven, CT; Medical Director, Yale Diabetes Center, Yale-New Haven Hospital, New Haven, CT.
Department of Endocrinology, Yale University School of Medicine, New Haven, CT; Section of Endocrinology, Bridgeport Hospital, Yale New Haven Health System, Bridgeport, CT.
Med Clin North Am. 2015 Jan;99(1):47-67. doi: 10.1016/j.mcna.2014.08.018. Epub 2014 Nov 22.
Hyperglycemia is the unifying metabolic abnormality for all forms of diabetes mellitus, forming the basis for its diagnosis and treatment. The strong epidemiologic associations between hyperglycemia and the complications of diabetes have given rise to the glucose hypothesis-that the complications of diabetes are caused by hyperglycemia and that they can be prevented by normalizing glucose levels. Herein the authors review the epidemiologic relationships between hyperglycemia and the complications of diabetes, the major trials of glucose lowering, and the extent to which the glucose hypothesis is supported by these studies and how this information can be translated into clinical practice.
高血糖是所有类型糖尿病的共同代谢异常，是其诊断和治疗的基础。高血糖与糖尿病并发症之间的强烈流行病学关联催生了血糖假说，即糖尿病并发症是由高血糖引起的，通过使血糖水平正常化可以预防这些并发症。本文作者回顾了高血糖与糖尿病并发症之间的流行病学关系、降低血糖的主要试验，以及这些研究在多大程度上支持血糖假说，以及如何将这些信息转化为临床实践。
