[超氧阴离子氧自由基的光生成及其在长波紫外线对酵母细胞失活中的作用]
[Photogeneration of the superoxide anion oxygen radical and its role in the inactivation of yeast cells by long-wave UV light].
作者信息
Pospelov M E, Fraĭkin G Ia
出版信息
Izv Akad Nauk SSSR Biol. 1989 Mar-Apr(2):308-11.
PMID:2545760
Abstract
Long-wave (320-400 nm) UV-induced oxygen superoxide anion radical (O2-) formation was found in yeast cells. This radical plays an important part in initiation of photodestruction reactions in DNA which serves as a main target of UV irradiation in yeast. The observed cell photoinactivation spectrum at the wavelengths 320-400 nm suggests that NADH can serve as an endogenous sensitizer of O2- formation.
摘要
在酵母细胞中发现了长波（320 - 400纳米）紫外线诱导的超氧阴离子自由基（O₂⁻）的形成。该自由基在DNA光破坏反应的起始过程中起重要作用，而DNA是酵母中紫外线照射的主要靶点。在320 - 400纳米波长处观察到的细胞光失活光谱表明，NADH可作为O₂⁻形成的内源性敏化剂。
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