Hamlin Brian R, DiGioia Anthony M, Plakseychuk Anton Y, Levison Tim J
The Bone & Joint Center, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
J Arthroplasty. 2015 Mar;30(3):384-6. doi: 10.1016/j.arth.2014.10.007. Epub 2014 Oct 12.
The objective of this study is to compare the effectiveness of intravenous versus topical application of tranexamic acid in patients undergoing knee arthroplasty. All patients who underwent primary knee arthroplasty at our total joint center over a 12-month period were included in the study. One surgeon utilized 1 g of IV TXA at time of incision in all patients (n=373) except those with a documented history of venous thromboembolism (VTE). Two surgeons utilized a topical application of TXA for all patients without exception (n=198) in which the joint was injected after capsular closure with 3 g TXA/100 mL saline. The transfusion rate was 0% in the topical group vs. 2.4% in the IV group and this was statistically significant (P<0.05).
本研究的目的是比较氨甲环酸静脉注射与局部应用在接受膝关节置换术患者中的有效性。在我们的全关节中心，对12个月内接受初次膝关节置换术的所有患者进行了研究。除有静脉血栓栓塞（VTE）病史记录的患者外，一名外科医生在所有患者（n = 373）手术切口时使用1 g静脉注射氨甲环酸。两名外科医生无一例外对所有患者（n = 198）采用氨甲环酸局部应用，即在关节囊闭合后用3 g氨甲环酸/100 mL生理盐水进行关节注射。局部应用组的输血率为0%，静脉注射组为2.4%，差异具有统计学意义（P<0.05）。
