纳米纤维素-藻酸盐水凝胶用于细胞包封。
Nanocellulose-alginate hydrogel for cell encapsulation.
机构信息
Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151-921, Republic of Korea.
Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151-921, Republic of Korea; Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Republic of Korea.
出版信息
Carbohydr Polym. 2015 Feb 13;116:223-8. doi: 10.1016/j.carbpol.2014.07.059. Epub 2014 Aug 4.
TEMPO-oxidized bacterial cellulose (TOBC)-sodium alginate (SA) composites were prepared to improve the properties of hydrogel for cell encapsulation. TOBC fibers were obtained using a TEMPO/NaBr/NaClO system at pH 10 and room temperature. The fibrillated TOBCs mixed with SA were cross-linked in the presence of Ca(2+) solution to form hydrogel composites. The compression strength and chemical stability of the TOBC/SA composites were increased compared with the SA hydrogel, which indicated that TOBC performed an important function in enhancing the structural, mechanical and chemical stability of the composites. Cells were successfully encapsulated in the TOBC/SA composites, and the viability of cells was investigated. TOBC/SA composites can be a potential candidate for cell encapsulation engineering.
TEMPO-氧化细菌纤维素（TOBC）-海藻酸钠（SA）复合材料的制备旨在改善用于细胞包封的水凝胶的性能。使用 TEMPO/NaBr/NaClO 体系在 pH 10 和室温下获得 TOBC 纤维。将纤维状 TOBC 与 SA 混合，在 Ca(2+)溶液的存在下交联形成水凝胶复合材料。与 SA 水凝胶相比，TOBC/SA 复合材料的压缩强度和化学稳定性得到提高，这表明 TOBC 在增强复合材料的结构、机械和化学稳定性方面发挥了重要作用。细胞成功地包封在 TOBC/SA 复合材料中，并研究了细胞的活力。TOBC/SA 复合材料可能是细胞包封工程的潜在候选材料。
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