肥胖和非肥胖多囊卵巢综合征女性体内的巨噬细胞移动抑制因子
Macrophage migration inhibitory factor in obese and non obese women with polycystic ovary syndrome.
作者信息
Mejia-Montilla Jorly, Álvarez-Mon Melchor, Reyna-Villasmil Eduardo, Torres-Cepeda Duly, Santos-Bolívar Joel, Reyna-Villasmil Nadia, Suarez-Torres Ismael, Bravo-Henríquez Alfonso
机构信息
Servicio de Ginecología, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela.
Departamento de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
出版信息
Endocrinol Nutr. 2015 Jan;62(1):31-7. doi: 10.1016/j.endonu.2014.09.005. Epub 2014 Nov 15.
OBJECTIVE
To measure macrophage migration inhibitory factor (MIF) concentrations in obese and non-obese women diagnosed with polycystic ovary syndrome (PCOS).
METHODS
Women diagnosed with PCOS and age-matched healthy controls with regular menses and normal ovaries on ultrasound examination were selected and divided into 4 groups (group A, PCOS and obese; group B, PCOS and non-obese; group C, obese controls; and group D, non-obese controls) based on body mass index (obese >30 kg/m2 and non-obese <25 kg/m2). Luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, sex hormone-binding globulin, serum glucose, insulin and MIF levels were measured.
RESULTS
Obese and non-obese women with PCOS had higher luteinizing hormone, follicle-stimulating hormone, androstenedione, testosterone, and insulin levels as compared to the obese and non-obese control groups, respectively (P < .0001). Women with PCOS had significantly higher MIF levels (group A, 48.6 ± 9.9 mg/ml; group B, 35.2 ± 6.0 ng/ml) as compared to controls (group C, 13.5 ± 6.0 ng/ml; group D, 12.0 ± 4.3 ng/dl; P < .0001). A weak, positive and significant correlation was seen between fasting blood glucose and insulin levels in women with PCOS (P < .05).
CONCLUSION
Significant differences exist in plasma MIF levels between obese and non-obese women with and without PCOS.
目的
测量诊断为多囊卵巢综合征（PCOS）的肥胖和非肥胖女性体内巨噬细胞移动抑制因子（MIF）的浓度。
方法
选取诊断为PCOS的女性以及年龄匹配的月经规律且超声检查卵巢正常的健康对照者，根据体重指数（肥胖>30 kg/m²，非肥胖<25 kg/m²）分为4组（A组，PCOS且肥胖；B组，PCOS且非肥胖；C组，肥胖对照；D组，非肥胖对照）。测量促黄体生成素、促卵泡生成素、雄烯二酮、睾酮、性激素结合球蛋白、血糖、胰岛素和MIF水平。
结果
与肥胖和非肥胖对照组相比，患有PCOS的肥胖和非肥胖女性的促黄体生成素、促卵泡生成素、雄烯二酮、睾酮和胰岛素水平分别更高（P <.0001）。与对照组相比，患有PCOS的女性的MIF水平显著更高（A组，48.6±9.9 mg/ml；B组，35.2±6.0 ng/ml）（C组，13.5±6.0 ng/ml；D组，12.0±4.3 ng/dl；P <.0001）。PCOS女性的空腹血糖与胰岛素水平之间存在微弱、正性且显著的相关性（P <.05）。
结论
患有和未患有PCOS的肥胖和非肥胖女性之间血浆MIF水平存在显著差异。
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