布氏布氏锥虫和伊氏锥虫混合感染对Wistar大鼠骨髓的致断裂效应。
Clastogenic effects of Trypanosoma brucei brucei and Trypanosoma evansi mixed infection in bone marrow of Wistar rats.
作者信息
Habila Nathan, Muhammad Aliyu, Ndidi Uche S, Chechet Gloria D, Aimola Idowu A, Olalekan Bello A
机构信息
Department of Biochemistry, Ahmadu Bello University Zaria, Kaduna State 810001, Nigeria; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic. 3800, Australia.
Department of Biochemistry, Ahmadu Bello University Zaria, Kaduna State 810001, Nigeria.
出版信息
Res Vet Sci. 2014 Dec;97(3):550-3. doi: 10.1016/j.rvsc.2014.09.018. Epub 2014 Oct 16.
The clastogenic effect of mixed infection of Trypanosoma evansi and Trypanosoma brucei brucei in the bone marrow (BM) cells of Wistar albino rats was investigated. Clastogenic effects were observed in the BM cells using the micronucleus assay. The findings indicate that T. evansi, T. b. brucei and mixed infection with both parasites induced the formation of micronucleated polychromatic erythrocyte (MN-PCEs) in the BM cells significantly (P < 0.05) by 60, 63 and 81 micronuclei/1000 PCE respectively. Mixed infection induced formation of MN-PCEs increase by about 1.33 fold when compared with single infections of T. b. brucei and T. evansi. These data give a preliminary evidence of possible genotoxic effects in trypanosomiasis.
研究了伊氏锥虫和布氏布氏锥虫混合感染对Wistar白化大鼠骨髓（BM）细胞的致断裂效应。使用微核试验观察BM细胞中的致断裂效应。研究结果表明，伊氏锥虫、布氏布氏锥虫以及两种寄生虫的混合感染均能显著诱导BM细胞中微核多染红细胞（MN-PCEs）的形成（P < 0.05），分别为每1000个PCE中有60、63和81个微核。与布氏布氏锥虫和伊氏锥虫的单一感染相比，混合感染诱导的MN-PCEs形成增加了约1.33倍。这些数据初步证明了锥虫病可能存在的遗传毒性作用。
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