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Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria.

作者信息

Demon Dieter, Vande Walle Lieselotte, Lamkanfi Mohamed

机构信息

Department of Medical Protein Research, VIB, Ghent, B-9000, Belgium; Department of Biochemistry, Ghent University, Ghent, B-9000, Belgium.

Department of Medical Protein Research, VIB, Ghent, B-9000, Belgium; Department of Biochemistry, Ghent University, Ghent, B-9000, Belgium.

出版信息

Trends Biochem Sci. 2014 Dec;39(12):574-6. doi: 10.1016/j.tibs.2014.10.006. Epub 2014 Nov 4.

DOI:10.1016/j.tibs.2014.10.006
PMID:25458607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4247376/
Abstract

Caspase-11 contributes to host defense against Gram-negative bacterial pathogens by inducing an inflammatory form of programmed cell death in infected cells. Lipopolysaccharides (LPS) have been identified as the microbial agents that stimulate caspase-11 activation; however, the mechanism of LPS detection has been unknown. In a recent study, Shao and colleagues demonstrate that caspase-11 and its human homologues, caspases -4 and -5, unexpectedly act as direct sensors of cytosolic LPS.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81d0/4247376/ead34f65bfd0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81d0/4247376/ead34f65bfd0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81d0/4247376/ead34f65bfd0/gr1.jpg

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2
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本文引用的文献

1
Inflammatory caspases are innate immune receptors for intracellular LPS.炎症小体是细胞内 LPS 的先天免疫受体。
Nature. 2014 Oct 9;514(7521):187-92. doi: 10.1038/nature13683. Epub 2014 Aug 6.
2
Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock.细胞质脂多糖激活半胱天冬酶-11：在 TLR4 非依赖性内毒素性休克中的意义。
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革兰氏阴性菌和寄生原虫的糖缀合物 - 它们在调控先天免疫反应方面是否相似？
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Inflammasomes and their roles in health and disease.炎症小体及其在健康和疾病中的作用。
Annu Rev Cell Dev Biol. 2012;28:137-61. doi: 10.1146/annurev-cellbio-101011-155745. Epub 2012 Sep 10.
7
Non-canonical inflammasome activation targets caspase-11.非经典炎性小体激活靶向半胱天冬酶-11。
Nature. 2011 Oct 16;479(7371):117-21. doi: 10.1038/nature10558.
8
Kinetics of binding of LPS to recombinant CD14, TLR4, and MD-2 proteins.脂多糖与重组CD14、Toll样受体4及髓样分化蛋白2的结合动力学
Mol Cells. 2007 Aug 31;24(1):119-24.
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Cell. 2004 Jun 25;117(7):855-8. doi: 10.1016/j.cell.2004.06.007.
10
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.小鼠半胱天冬酶-11是一种与ICE相互作用的蛋白酶，对ICE的激活至关重要。
Cell. 1998 Feb 20;92(4):501-9. doi: 10.1016/s0092-8674(00)80943-5.