Shao Yingjie, Geng Yiting, Gu Wendong, Ning Zhonghua, Jiang Jingting, Pei Honglei
Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou 213003, PR China.
Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou 213003, PR China.
Biomed Pharmacother. 2014 Oct;68(8):969-77. doi: 10.1016/j.biopha.2014.10.017. Epub 2014 Oct 29.
Recently, many studies have shown that the B-cell-specific moloney leukemia virus insertion site 1 (Bmi-1) exhibits altered expression in various cancers and may serve as prognostic biomarkers. We performed a meta-analysis to evaluate the prognostic role of Bmi-1 expression in solid cancers. Studies were recruited by searching PubMed, Embase and the Cochrane Library. Thirty-nine articles including 40 studies were involved in this meta-analysis. Our results indicated that the Bmi-1 showed the opposite prognostic effect in Asian and Caucasian populations. High Bmi-1 expression as a negative predictor for overall survival (OS) in Asian patients (HR=1.96, 95% CI 1.62-2.36), but a positive predictor in Caucasian populations (HR=0.77, 95% CI 0.63-0.93). Furthermore, we took a further subgroup analysis based on tumor type in these two populations, respectively. In Asian cases, high expression of Bmi-1 was associated with poor OS in oesophageal carcinoma (HR=1.93, 95% CI 1.52-2.46), gastric cancer (HR=1.50, 95% CI 1.22-1.85), lung cancer (HR=1.73, 95% CI 1.05-2.85), cervical cancer (HR=2.80, 95% CI 2.26-3.47) and colorectal cancer (HR=3.36, 95% CI 2.19-5.15), rather than in breast cancer and HCC. In Caucasian populations, high expression of Bmi-1 was associated with better OS in breast cancer (HR=0.70, 95% CI 0.51-0.97), but it showed no significance in oesophageal carcinoma. In conclusion, high Bmi-1 expression was significantly associated with poor survival in Asian patients with oesophageal carcinoma, gastric cancer, lung cancer, colorectal cancer and cervical carcinoma, whereas high level of Bmi-1 can predict better prognosis in Caucasian patients with breast cancer.
最近，许多研究表明，B细胞特异性莫洛尼白血病病毒插入位点1（Bmi-1）在各种癌症中表达发生改变，可能作为预后生物标志物。我们进行了一项荟萃分析，以评估Bmi-1表达在实体癌中的预后作用。通过检索PubMed、Embase和Cochrane图书馆招募研究。本荟萃分析纳入了39篇文章，包括40项研究。我们的结果表明，Bmi-1在亚洲人和白种人群体中显示出相反的预后作用。高Bmi-1表达在亚洲患者中是总生存期（OS）的负性预测指标（HR=1.96，95%CI 1.62-2.36），但在白种人群体中是正性预测指标（HR=0.77，95%CI 0.63-0.93）。此外，我们分别在这两个人群体中基于肿瘤类型进行了进一步的亚组分析。在亚洲病例中，Bmi-1高表达与食管癌（HR=1.93，95%CI 1.52-2.46）、胃癌（HR=1.50，95%CI 1.22-1.85）、肺癌（HR=1.73，95%CI 1.05-2.85）、宫颈癌（HR=2.80，95%CI 2.26-3.47）和结直肠癌（HR=3.36，95%CI 2.19-5.15）的OS较差相关，而在乳腺癌和肝癌中并非如此。在白种人群体中，Bmi-1高表达与乳腺癌的OS较好相关（HR=0.70，95%CI 0.51-0.97），但在食管癌中无显著意义。总之，高Bmi-1表达与亚洲食管癌、胃癌、肺癌、结直肠癌和宫颈癌患者的不良生存显著相关，而高水平的Bmi-1可预测白种人乳腺癌患者的较好预后。
