Wang He-Ling, Zhou Ping-Yi, Liu Peng, Zhang Yu
Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, 110022, People's Republic of China,
Tumour Biol. 2014 Jul;35(7):6815-21. doi: 10.1007/s13277-014-1936-7. Epub 2014 Apr 12.
Our current meta-analysis is aimed to investigate the relationships between fragile histidine triad (FHIT) protein expression and prognosis in gastric cancer patients. We searched MEDLINE (1966 ~ 2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), Web of Science (1945 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013) without any language restrictions. The meta-analysis was conducted using the STATA 12.0 software. Crude hazard ratios (HR) with its 95 % confidence interval (95 % CI) were calculated. Eight clinical cohort studies with a total of 1,361 gastric cancer patients were involved in our meta-analysis. Our results revealed that FHIT-negative patients exhibited a shorter overall survival (OS) time than FHIT-positive patients (HR = 1.23, 95 % CI = 1.01 ~ 1.44, P < 0.001). Ethnicity-stratified analysis demonstrated that FHIT-negative patients have significantly poorer prognosis than FHIT-positive patients among both Caucasians and Asians (all P < 0.05). In conclusion, our meta-analysis provides evidences that negative expression of FHIT protein may be correlated with poor prognosis in patients with gastric cancer. Thus, FHIT expression level may be utilized as an independent prognostic marker for gastric cancer.
我们当前的荟萃分析旨在研究胃癌患者中脆性组氨酸三联体（FHIT）蛋白表达与预后之间的关系。我们检索了MEDLINE（1966年至2013年）、Cochrane图书馆数据库（2013年第12期）、EMBASE（1980年至2013年）、CINAHL（1982年至2013年）、科学网（1945年至2013年）以及中国生物医学数据库（CBM）（1982年至2013年），没有任何语言限制。使用STATA 12.0软件进行荟萃分析。计算了粗风险比（HR）及其95%置信区间（95%CI）。我们的荟萃分析纳入了八项临床队列研究，共1361例胃癌患者。我们的结果显示，FHIT阴性患者的总生存期（OS）比FHIT阳性患者短（HR = 1.23，95%CI = 1.01至1.44，P < 0.001）。种族分层分析表明，在白种人和亚洲人中，FHIT阴性患者的预后均显著差于FHIT阳性患者（所有P < 0.05）。总之，我们的荟萃分析提供了证据表明，FHIT蛋白的阴性表达可能与胃癌患者的不良预后相关。因此，FHIT表达水平可作为胃癌的独立预后标志物。
