Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Biotechnol Appl Biochem. 2021 Dec;68(6):1313-1322. doi: 10.1002/bab.2053. Epub 2020 Nov 2.
B-cell-specific Moloney leukemia virus insertion site 1 (BMI-1) is one of the stemness markers. The prognostic and clinicopathological effects of BMI-1 expression in colorectal cancer (CRC) have been in dispute with different studies. Eligible studies were retrieved from international databases up to December 2019. Studies with a relationship between the clinicopathological and prognostic value of CRC patients with BMI-1 expression were selected. The correlations in the random-effect model were evaluated using the hazard ratios, odds ratio, and 95% confidence intervals (CIs). A total of nine studies comprising Asian cases (seven studies) and European cases (two studies) covering 1,294 samples of CRC were included for this meta-analysis. The analysis suggested that in Asian cases, increased expression of BMI-1 was associated with poor overall survival (OS) and death-free survival, whereas in European populations, high expression of BMI-1 was associated with better OS. Also, overexpression of BMI-1 in the Asian population was associated with the tumor size, distant metastasis, and patient's gender and age. Results suggested that high expression of BMI-1 can be involved in the progression and invasion of CRC, and so its inhibitor-based therapies could be used to prevent the progression of CRC.
B 细胞特异性 Moloney 白血病病毒插入位点 1（BMI-1）是干性标志物之一。BMI-1 在结直肠癌（CRC）中的表达的预后和临床病理影响存在争议，不同的研究结果不一。检索截至 2019 年 12 月的国际数据库中符合条件的研究。选择研究 BMI-1 表达与 CRC 患者临床病理和预后价值之间关系的研究。使用风险比、优势比和 95%置信区间（CI）评估随机效应模型中的相关性。共有 9 项研究纳入了亚洲病例（7 项研究）和欧洲病例（2 项研究）共 1294 例 CRC 样本，进行了荟萃分析。分析表明，在亚洲病例中，BMI-1 表达增加与总生存期（OS）和无病生存期不良相关，而在欧洲人群中，BMI-1 高表达与 OS 较好相关。此外，BMI-1 在亚洲人群中的过表达与肿瘤大小、远处转移以及患者的性别和年龄有关。结果表明，BMI-1 的高表达可能参与了 CRC 的进展和侵袭，因此基于其抑制剂的治疗方法可用于预防 CRC 的进展。
