Ness Kirsten K, Neel Michael D, Kaste Sue C, Billups Catherine A, Marchese Victoria G, Rao Bhaskar N, Daw Najat C
Eur J Cancer. 2014 Dec;50(18):3212-20. doi: 10.1016/j.ejca.2014.10.005.
Modular and non-invasive expandable prostheses have been developed to provide a functional knee joint that allows future expansion as growth occurs in the contralateral extremity in children with bone sarcomas that require removal of the growth plate. This study aimed to evaluate the functional outcomes of paediatric patients who received either a non-invasive expandable or modular prosthesis for bone sarcomas arising around the knee.
We evaluated clinician-reported, patient-reported and measured function in 42 paediatric patients at least one year (median age at assessment 19.1 years) after limb salvage surgery, and compared patients who received modular system prostheses (N = 29, median age 15.5), who did not require lengthening procedures to those who received non-invasive expandable prostheses (N = 13, median age 11.1) requiring lengthening procedures (median 5).
The number of revisions and time to first revision did not differ between the two groups. There were no differences between the two groups in total scores on the Enneking Musculoskeletal Tumor Society Scale, the Toronto Extremity Salvage Scale, and the Functional Mobility Assessment. Children with non-invasive expandable prostheses climbed stairs (11.93 ± 4.83 versus 16.73 ± 7.24 s, p = 0.02) in less time than those with modular prostheses.
Our results suggest that the non-invasive expandable prosthesis produces similar functional results to the more traditional modular prosthesis.
已研发出模块化和非侵入性可扩张假体,以提供一个功能性膝关节,使其能在需要切除生长板的骨肉瘤患儿对侧肢体生长时实现未来的扩张。本研究旨在评估接受非侵入性可扩张或模块化假体治疗膝关节周围骨肉瘤的儿科患者的功能结局。
我们评估了42例儿科患者在保肢手术后至少一年(评估时的中位年龄为19.1岁)由临床医生报告、患者报告及测量的功能,并将接受模块化系统假体(N = 29,中位年龄15.5岁)且不需要延长手术的患者与接受非侵入性可扩张假体(N = 13,中位年龄11.1岁)且需要延长手术(中位次数为5次)的患者进行比较。
两组之间的翻修次数和首次翻修时间无差异。两组在恩内肯肌肉骨骼肿瘤学会量表、多伦多肢体挽救量表和功能活动评估的总分上没有差异。使用非侵入性可扩张假体的儿童爬楼梯所用时间(11.93±4.83秒对16.73±7.24秒,p = 0.02)比使用模块化假体的儿童少。
我们的结果表明,非侵入性可扩张假体产生的功能结果与更传统的模块化假体相似。