Harvey Richard P, Graham Robert M, Pu William T
Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst 2010, New South Wales, Australia.
Department of Cardiology, Boston Children's Hospital, Enders 1254, 300 Longwood Ave, Boston, MA 02115, USA.
Stem Cell Res. 2014 Nov;13(3 Pt B):521-2. doi: 10.1016/j.scr.2014.10.003. Epub 2014 Oct 12.
Despite therapeutic advances that slow its progression, heart disease remains the world's leading cause of death. Until recently, the "Holy Grail" of cardiac biology, to regenerate the damaged heart, appeared to be a fantastical and quixotic quest. However, recent studies showing that the mammalian heart possesses an innate, albeit limited, regenerative capacity offer hope that effective cardiac regeneration may be an attainable goal. This Special Issue of Stem Cell Research reviews the remarkable progress that has been made in this field in the last few years.
尽管治疗方法的进步减缓了心脏病的发展进程，但心脏病仍是全球首要死因。直到最近，心脏生物学的“圣杯”——让受损心脏再生，似乎仍是一个不切实际、荒诞不经的追求。然而，最近的研究表明，哺乳动物的心脏具有一种内在的、尽管有限的再生能力，这给人们带来了希望，即有效的心脏再生可能是一个可以实现的目标。本期干细胞研究特刊回顾了该领域在过去几年中取得的显著进展。
