基于核壳型 Fe3O4@C 纳米粒子和分子印迹 TiO2 的尿酸高选择性光电化学生物传感器。
A highly selective photoelectrochemical biosensor for uric acid based on core-shell Fe3O4@C nanoparticle and molecularly imprinted TiO2.
机构信息
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China; Institute of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
出版信息
Biosens Bioelectron. 2015 Mar 15;65:115-20. doi: 10.1016/j.bios.2014.10.013. Epub 2014 Oct 16.
Combining the surface modification and molecular imprinting technique, a novel photoelectrochemical sensing platform with excellent photochemical catalysis and molecular recognition capabilities was established for the detection of uric acid based on the magnetic immobilization of Fe3O4@C nanoparticles onto magnetic glassy carbon electrode (MGCE) and modification of molecularly imprinted TiO2 film on Fe3O4@C. The developed biosensor was highly sensitive to uric acid in solutions, with a linear range from 0.3 to 34µM and a limit of detection of 0.02μM. Furthermore, the biosensor exhibited outstanding selectivity while used in coexisting systems containing various interferents with high concentration. The practical application of the biosensor was also realized for the selective detection of uric acid in spiked samples. The study made a successful attempt in the development of highly selective and sensitive photoelectrochemical biosensor for urine monitoring.
结合表面修饰和分子印迹技术，通过将 Fe3O4@C 纳米粒子磁性固定在磁性玻碳电极（MGCE）上，并在 Fe3O4@C 上修饰分子印迹 TiO2 薄膜，构建了一种具有优异光化学催化和分子识别能力的新型光电化学传感平台，用于尿酸的检测。所开发的生物传感器对溶液中的尿酸具有高灵敏度，线性范围为 0.3 至 34µM，检测限为 0.02μM。此外，该生物传感器在含有高浓度各种干扰物的共存体系中表现出出色的选择性。该生物传感器还成功地应用于实际样品中尿酸的选择性检测。该研究在开发用于尿液监测的高选择性和高灵敏度光电化学生物传感器方面取得了成功尝试。
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