Mula M, Iudice A, La Neve A, Mazza M, Mazza S, Cantello R, Kanner A M
Epilepsy Group, Atkinson Morley Regional Neuroscience Centre, St George's Hospital and Institute of Medical and Biomedical Sciences, St George's University of London, UK.
Division of Neurology, University of Pisa, Italy.
Epilepsy Behav. 2014 Dec;41:122-5. doi: 10.1016/j.yebeh.2014.08.029. Epub 2014 Oct 16.
Mood disorders represent a frequent psychiatric comorbidity among patients with epilepsy, having a major impact on their quality of life and contributing considerably to the global burden of the disease. The availability of standardized clinical instruments validated in populations with epilepsy has important implications in terms of diagnosis and treatment. This aimed to validate the Hamilton Rating Scale for Depression (HRSD) in adult patients with epilepsy.
A consecutive sample of 120 adult outpatients with epilepsy was assessed using the Mini International Neuropsychiatric Inventory (MINI) Plus version 5.0.0 and the HRSD.
Cronbach's alpha coefficient was 0.824 for the 17-item version and 0.833 for the 21-item version. Receiver operating characteristic analysis showed an area under the curve of 0.896 and 0.899, respectively, for the two versions. However, the HRSD-17 demonstrated the best psychometric properties compared to the HRSD-21 and, with a cutoff score of 6, showed a sensitivity of 94%, a specificity of 80%, a positive predictive value of 46%, and a negative predictive value of 99%.
The HRSD proved to be reliable and valid in the epilepsy setting and will stimulate further research in this area.
情绪障碍是癫痫患者中常见的精神共病，对其生活质量有重大影响，并在很大程度上加重了该疾病的全球负担。在癫痫患者群体中经过验证的标准化临床工具的可用性在诊断和治疗方面具有重要意义。本研究旨在验证成人癫痫患者的汉密尔顿抑郁量表（HRSD）。
使用迷你国际神经精神访谈量表（MINI）5.0.0版和HRSD对120例成年癫痫门诊患者的连续样本进行评估。
17项版本的克朗巴哈α系数为0.824，21项版本的为0.833。受试者工作特征分析显示，两个版本的曲线下面积分别为0.896和0.899。然而，与HRSD - 21相比，HRSD - 17表现出最佳的心理测量特性，截断分数为6时，其敏感性为94%，特异性为80%，阳性预测值为46%，阴性预测值为99%。
HRSD在癫痫环境中被证明是可靠且有效的，并将推动该领域的进一步研究。
