Mazzon Ivan, Favilli Alessandro, Horvath Stefano, Grasso Mario, Di Renzo Gian Carlo, Laurenti Elena, Bini Vittorio, Gerli Sandro
"Arbor Vitae" Centre, Clinica Nuova Villa Claudia, 00191 Rome, Italy.
Department of Obstetrics and Gynecology, University of Perugia, S.M. della Misericordia Hospital, 06156 Perugia, Italy.
Eur J Obstet Gynecol Reprod Biol. 2014 Dec;183:169-73. doi: 10.1016/j.ejogrb.2014.10.045. Epub 2014 Oct 30.
To evaluate whether a correlation exists between the pain perceived during diagnostic anesthesia-free hysteroscopy and the characteristics of the cervical canal.
Prospective observational pilot study of 255 women undergoing diagnostic hysteroscopy. Data analysis included characteristics of the patient and the cervical canal, and the pain experience during the procedure, assessed by visual analog score (VAS). A multiple logistic regression was then carried out in order to exclude confounding factors.
The degree of pain during hysteroscopy was equal to a median VAS score of 2 (range 0-10). Bivariate analysis between patients with VAS>3 and patients with VAS≤3 demonstrated a significant correlation between pain and the presence of synechiae in the cervical canal (P=0.022), the patient's age (P=0.003) and parity (P=0.001). Multivariate analysis revealed that the presence of cervical synechiae (P=0.0001) [OR=4.99 (95% CI 2.13-11.70)] and parity (P=0.014) [OR=0.42 (95% CI 0.21-0.83)] were significantly correlated with pain. There was no significant correlation with the different angles of the cervical canal.
Cervical synechiae appear as a major factor influencing pain during hysteroscopy. While parity acts as a protective factor, the angle of the cervical canal does not seem to play an important role for pain during diagnostic hysteroscopy.
评估在诊断性无麻醉宫腔镜检查过程中所感知的疼痛与宫颈管特征之间是否存在相关性。
对255例行诊断性宫腔镜检查的女性进行前瞻性观察性初步研究。数据分析包括患者和宫颈管的特征,以及通过视觉模拟评分法(VAS)评估的手术过程中的疼痛体验。随后进行多因素逻辑回归分析以排除混杂因素。
宫腔镜检查期间的疼痛程度相当于VAS评分中位数为2(范围0 - 10)。VAS>3的患者与VAS≤3的患者之间的双变量分析表明,疼痛与宫颈管粘连的存在(P = 0.022)、患者年龄(P = 0.003)和产次(P = 0.001)之间存在显著相关性。多变量分析显示,宫颈粘连的存在(P = 0.0001)[比值比(OR)= 4.99(95%可信区间2.13 - 11.70)]和产次(P = 0.014)[OR = 0.42(95%可信区间0.21 - 0.83)]与疼痛显著相关。与宫颈管的不同角度无显著相关性。
宫颈粘连似乎是影响宫腔镜检查期间疼痛的主要因素。产次起到保护作用,而宫颈管角度在诊断性宫腔镜检查期间对疼痛似乎不起重要作用。