Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom.
Department of Infectious Disease Epidemiology, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom.
Curr Opin Microbiol. 2015 Feb;23:62-7. doi: 10.1016/j.mib.2014.11.004. Epub 2014 Nov 22.
New sequencing technologies have made it possible to generate bacterial genomes at clinically relevant timescales and price levels. The use of whole-genome sequencing (WGS) has proved useful for investigating transmission at different scales. WGS data are highly effective at determining whether individuals are part of the same transmission chain, making it possible to detect probable direct transmission events, delimit the extent of local nosocomial or community-based outbreaks, and identify worldwide patterns of spread and long-term dynamics of bacterial pathogens. Making the most of WGS data will probably always require associated detailed epidemiological data, but nevertheless it promises to become an increasingly valuable tool for infection control in the near future.
新型测序技术使我们能够在临床相关的时间范围内和价格水平上生成细菌基因组。全基因组测序（WGS）的应用已被证明对于研究不同规模的传播非常有用。WGS 数据在确定个体是否属于同一传播链方面非常有效，从而可以检测可能的直接传播事件，划定局部医院内或社区暴发的范围，并识别细菌病原体的全球传播模式和长期动态。充分利用 WGS 数据可能始终需要相关的详细流行病学数据，但它有望成为未来感染控制的一个越来越有价值的工具。
