Sintchenko Vitali, Iredell Jonathan R, Gilbert Gwendolyn L
Centre for Infectious Diseases and Microbiology Public Health, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Western Clinical School, The University of Sydney, New South Wales, Australia.
Nat Rev Microbiol. 2007 Jun;5(6):464-70. doi: 10.1038/nrmicro1656. Epub 2007 May 8.
The usefulness of rapid pathogen genotyping is widely recognized, but its effective interpretation and application requires integration into clinical and public health decision-making. How can pathogen genotyping data best be translated to inform disease management and surveillance? Pathogen profiling integrates microbial genomics data into communicable disease control by consolidating phenotypic identity-based methods with DNA microarrays, proteomics, metabolomics and sequence-based typing. Sharing data on pathogen profiles should facilitate our understanding of transmission patterns and the dynamics of epidemics.
快速病原体基因分型的实用性已得到广泛认可，但其有效解读和应用需要融入临床和公共卫生决策之中。如何才能最好地转化病原体基因分型数据以指导疾病管理和监测？病原体分析通过将基于表型特征的方法与DNA微阵列、蛋白质组学、代谢组学及基于序列的分型方法相结合，将微生物基因组学数据整合到传染病控制中。共享病原体分析数据应有助于我们理解传播模式和疫情动态。
