黄病毒非结构蛋白5（NS5）：结构、功能以及疫苗和治疗药物研发的靶点
The Flavivirus Non-Structural Protein 5 (NS5): Structure, Functions, and Targeting for Development of Vaccines and Therapeutics.
作者信息
Goh Jarvis Z H, De Hayr Lachlan, Khromykh Alexander A, Slonchak Andrii
机构信息
Australian Infectious Diseases Research Center, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD 4072, Australia.
出版信息
Vaccines (Basel). 2024 Aug 1;12(8):865. doi: 10.3390/vaccines12080865.
Flaviviruses, including dengue (DENV), Zika (ZIKV), West Nile (WNV), Japanese encephalitis (JEV), yellow fever (YFV), and tick-borne encephalitis (TBEV) viruses, pose a significant global emerging threat. With their potential to cause widespread outbreaks and severe health complications, the development of effective vaccines and antiviral therapeutics is imperative. The flaviviral non-structural protein 5 (NS5) is a highly conserved and multifunctional protein that is crucial for viral replication, and the NS5 protein of many flaviviruses has been shown to be a potent inhibitor of interferon (IFN) signalling. In this review, we discuss the functions of NS5, diverse NS5-mediated strategies adopted by flaviviruses to evade the host antiviral response, and how NS5 can be a target for the development of vaccines and antiviral therapeutics.
黄病毒，包括登革热病毒（DENV）、寨卡病毒（ZIKV）、西尼罗河病毒（WNV）、日本脑炎病毒（JEV）、黄热病毒（YFV）和蜱传脑炎病毒（TBEV），对全球构成了重大的新出现威胁。鉴于它们有可能引发广泛的疫情和严重的健康并发症，开发有效的疫苗和抗病毒疗法势在必行。黄病毒非结构蛋白5（NS5）是一种高度保守且多功能的蛋白质，对病毒复制至关重要，并且许多黄病毒的NS5蛋白已被证明是干扰素（IFN）信号传导的有效抑制剂。在这篇综述中，我们讨论了NS5的功能、黄病毒为逃避宿主抗病毒反应而采用的多种NS5介导的策略，以及NS5如何成为疫苗和抗病毒疗法开发的靶点。
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