Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500 Yunnan, PR China.
Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500 Yunnan, PR China.
Ecotoxicol Environ Saf. 2015 Feb;112:169-76. doi: 10.1016/j.ecoenv.2014.11.004. Epub 2014 Nov 19.
Bioaccumulation and effects of 17β-estradiol (E2) and 17α-ethynylestradiol (EE2) were assessed by crucian carp (Carassius auratus) following single and binary mixture exposures in flow-through exposure system for 16 months. In comparison with water control (DWC) and solvent control (SC), a significant reduction in body weight, body length and gonadosomatic index (GSI), and increase in hepatosomatic index (HSI) and plasma vitellogenin (VTG) levels were observed, in a time- and concentration-dependent manner. Bioconcentration factors (BCFs) of E2 and EE2 in fish muscle ranged from 3.2 to 40 and from 64 to 123, respectively. Crucian carp were found to be more sensitive to EE2 than E2. The bioaccumulation and toxicological effects in binary mixture exposed fish (mixture of E2 and EE2) were more significant than exposure of individual compound. Crucian carp is sensitive to E2 and EE2 in long-term laboratory exposure experiments and can be used as a potential model species for investigating the toxicity of hormones.
采用流水式暴露系统，对鲫鱼（Carassius auratus）进行了为期 16 个月的单一和二元混合物暴露实验，评估了 17β-雌二醇（E2）和 17α-乙炔基雌二醇（EE2）的生物累积和效应。与水对照（DWC）和溶剂对照（SC）相比，鲫鱼体重、体长和性腺指数（GSI）显著降低，肝体指数（HSI）和血浆卵黄蛋白原（VTG）水平显著升高，且呈时间和浓度依赖性。E2 和 EE2 在鲫鱼肌肉中的生物浓缩系数（BCF）分别为 3.2 至 40 和 64 至 123。鲫鱼对 EE2 的敏感性高于 E2。二元混合物暴露（E2 和 EE2 混合物）鱼类的生物累积和毒理学效应比单一化合物暴露更为显著。鲫鱼对长期实验室暴露实验中的 E2 和 EE2 敏感，可作为研究激素毒性的潜在模式生物。
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